STAT5B

STAT5B

A gene on chromosome 17q11.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT5B protein product is activated by and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin and various growth hormones.

Molecular pathology
In a subset of acute promyelocytic leukaemias, STAT5B fuses to RARA (retinoic acid receptor-alpha), resulting in signalling pathway dysregulation that may cause APLL.
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The DR did not affect the expression of genes for other GH signaling, including STAT5B, IGF-1, and myostatin, at either P1 or P2.
230) STAT5B, which promotes cell growth, is also activated by NPM-ALK via JAK2, although the downstream mediators have yet to be elucidated.
Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.