STAT5B

A gene on chromosome 17q11.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT5B protein product is activated by and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin and various growth hormones.

Molecular pathology
In a subset of acute promyelocytic leukaemias, STAT5B fuses to RARA (retinoic acid receptor-alpha), resulting in signalling pathway dysregulation that may cause APLL.

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References in periodicals archive ?

The DR did not affect the expression of genes for other GH signaling, including STAT5B, IGF-1, and myostatin, at either P1 or P2.

Effects of dietary restriction on the expression of lipid metabolism and growth hormone signaling genes in the longissimus dorsi muscle of Korean cattle steers

230) STAT5B, which promotes cell growth, is also activated by NPM-ALK via JAK2, although the downstream mediators have yet to be elucidated.

Anaplastic large cell lymphoma: twenty-five years of discovery

Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.