STAT5A

STAT5A

A gene on chromosome 17q11.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT5A protein product is activated by and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin and various growth hormones.

Molecular pathology
STAT5A activation in myeloma and lymphoma and TEL/JAK2 gene fusion is essential for tumourigenesis.
Mentioned in ?
References in periodicals archive ?
(2008) found that the expression level of PRLR tended to be opposite to that of STAT5a in common breast epithelial cells.
Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and stat5a. Oncogene 2015;34:3676-87.
Stephens, "STAT5A Expression in Swiss 3T3 Cells Promotes Adipogenesis In Vivo in an Athymic Mice Model System," Obesity, vol.
Hendricks et al., "Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a," Oncogene, vol.
The expression of PPAR[gamma] (Figure 4(d)), STAT5A (Figure 4(e)), and SREBP 1c (Figure 4(f)) was established.
In NAFLD&NASH, we observed that oxidative stress could activate epidermal growth factor receptor (EGFR) to facilitate (i) UBC to repress HSF1 in the WNT and MAPK signaling pathways; (ii) APP to activate ETS1 in the MAPK signaling pathway to induce DNA repair function through the mediation of RFC5, to activate metabolism through the mediation of TRMT1, and to inhibit apoptosis through the mediation of ZNF480; and (iii) SHC1 to repress STAT5A in the MAPK signaling pathway.
[5.] Nakajima H, Liu XW, Wynshaw-Boris A, et al An indirect effect of Stat5a in IL-2- induced proliferation: a critical role for Stat5a in IL-2- mediated IL-2 receptor alpha chain induction.
The carcinoma was positive for cytokeratin (CK) 7 (Figure 1, G), CK18, mammaglobin (Figure 1, H), S100 protein (S100) (Figure 1, I), and signal transducer and activator of transcription 5a (STAT5a); focally positive for p63 protein (p63); and negative for gross cystic disease fluid protein 15 (GCDFP-15), discovered on GIST-1 (DOG1), smooth muscle actin (SMA), calponin, and estrogen receptor/ progesterone receptor (ER/PR).
Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds.
Four types of JAK (JAK1, JAK2, JAK3, and Tyk2) and seven types of STAT (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6) proteins exist.
Hennighausen, "Stat5a is mandatory for adult mammary gland development and lactogenesis," Genes & Development, vol.
In mammals, the STAT family is comprised of seven members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6) and there are four tyrosine kinases identified (JAK1, JAK2, JAK3, and TYK2) [10].