STAT5A

STAT5A

A gene on chromosome 17q11.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT5A protein product is activated by and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin and various growth hormones.

Molecular pathology
STAT5A activation in myeloma and lymphoma and TEL/JAK2 gene fusion is essential for tumourigenesis.
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(2008) found that the expression level of PRLR tended to be opposite to that of STAT5a in common breast epithelial cells.
Construction and Evaluation of Novel Plasmid DNA Encoding Somatostatin Fused to a Tissue Plasminogen Activator (tPA) in Mice
Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and stat5a. Oncogene 2015;34:3676-87.
MicroRNA Dysregulation and Steroid Hormone Receptor Expression in Uterine Tissues of Rats with Endometriosis during the Implantation Window
Stephens, "STAT5A Expression in Swiss 3T3 Cells Promotes Adipogenesis In Vivo in an Athymic Mice Model System," Obesity, vol.
Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPAR[gamma]/RXR Heterodimerization
Hendricks et al., "Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a," Oncogene, vol.
Nonredundant, Highly Connected MicroRNAs Control Functionality in Breast Cancer Networks
The expression of PPAR[gamma] (Figure 4(d)), STAT5A (Figure 4(e)), and SREBP 1c (Figure 4(f)) was established.
Evaluation of Oxidative Stress and Mitophagy during Adipogenic Differentiation of Adipose-Derived Stem Cells Isolated from Equine Metabolic Syndrome (EMS) Horses
In NAFLD&NASH, we observed that oxidative stress could activate epidermal growth factor receptor (EGFR) to facilitate (i) UBC to repress HSF1 in the WNT and MAPK signaling pathways; (ii) APP to activate ETS1 in the MAPK signaling pathway to induce DNA repair function through the mediation of RFC5, to activate metabolism through the mediation of TRMT1, and to inhibit apoptosis through the mediation of ZNF480; and (iii) SHC1 to repress STAT5A in the MAPK signaling pathway.
Investigating Pathogenic and Hepatocarcinogenic Mechanisms from Normal Liver to HCC by Constructing Genetic and Epigenetic Networks via Big Genetic and Epigenetic Data Mining and Genome-Wide NGS Data Identification
[5.] Nakajima H, Liu XW, Wynshaw-Boris A, et al An indirect effect of Stat5a in IL-2- induced proliferation: a critical role for Stat5a in IL-2- mediated IL-2 receptor alpha chain induction.
Characterization of porcine cytokine inducible SH2-containing protein gene and its association with piglet diarrhea traits
The carcinoma was positive for cytokeratin (CK) 7 (Figure 1, G), CK18, mammaglobin (Figure 1, H), S100 protein (S100) (Figure 1, I), and signal transducer and activator of transcription 5a (STAT5a); focally positive for p63 protein (p63); and negative for gross cystic disease fluid protein 15 (GCDFP-15), discovered on GIST-1 (DOG1), smooth muscle actin (SMA), calponin, and estrogen receptor/ progesterone receptor (ER/PR).
Updates on Immunohistochemical and Molecular Markers in Selected Head and Neck Diagnostic Problems
Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds.
RELATIONSHIP BETWEEN THE INSERTION/DELETION VARIANTS OF POU1F1, FSH, ANDMUC13 AND TESTIS MEASUREMENT TRAITS IN MALE PIGLETS
Four types of JAK (JAK1, JAK2, JAK3, and Tyk2) and seven types of STAT (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6) proteins exist.
Electroacupuncture at GV20 and ST36 Exerts Neuroprotective Effects via the EPO-Mediated JAK2/STAT3 Pathway in Cerebral Ischemic Rats
Hennighausen, "Stat5a is mandatory for adult mammary gland development and lactogenesis," Genes & Development, vol.
The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis
In mammals, the STAT family is comprised of seven members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6) and there are four tyrosine kinases identified (JAK1, JAK2, JAK3, and TYK2) [10].
Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis

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