STAT5A

STAT5A

A gene on chromosome 17q11.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT5A protein product is activated by and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin and various growth hormones.

Molecular pathology
STAT5A activation in myeloma and lymphoma and TEL/JAK2 gene fusion is essential for tumourigenesis.
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Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds.
Li, PhD, a professor in the Department of Medicine at UC San Diego, reported that a particular form of a signaling protein called STAT5A stabilizes the formation of heterochromatin (a form of chromosomal DNA), which in turn suppresses the ability of cancer cells to issue instructions to multiply and grow.
When we expressed either HP1 (the central component of heterochromatin) or unphosphorylated STAT5A in human cancer cells, many genes important for cancer growth are suppressed.
3 Inmunodeficiencia por deficiencia esporadica completa-Infeccion micobacterial atipica diseminada familiar STAT3 102582 17q21 No definido aun STAT5A 601511 No definido aun No definido aun SOCS1 603597 16p13.
Visker (2013) Effect of polymorphisms in the FASN, OLR1, PPARGC1A, PRL and STAT5A genes on bovine milk-fat composition.
The STAT5A gene, as a member of the interferon-tau, plays major role in milk production (Khatib et al.
Mutations in the STAT5A gene are associated with embryonic survival and milk composition in cattle.
215,231) Importantly, STAT5A (a potent tumor suppressor) (232) and the negative regulator of the JAK/STAT pathway, SHP1 (SH2 domain-containing protein tyrosine phosphatase 1), are epigenetically silenced via DNA methylation.
Polymorphisms at loci of Leptin (LEP), Pit1 and STAT5A and their association with growth, feed conversion and carcass quality in Black-and- White bulls.