However, the abundance of hepatic JAK2 and STAT5
proteins are almost invariant during the periparturient period (unpublished data).
Expression of STAT5
protein was significantly higher in BP patients (131.37 [+ or -] 2.55) and DH patients (129.34 [+ or -] 1.37) as compared to the control group (123.48 [+ or -] 1.13; p < 0.05).
SOCS-3 does so by binding to the membrane proximal tyrosine residues recognized by STAT5
whereas CIS/SOCS-2 binds to more distal tyrosine residues (Krebs and Hilton, 2000; Krebs and Hilton, 2001).
In mouse studies it has been reported that the effect of FICZ on Th17 cell differentiation was associated with a reduction in Stat5
STAT1 may antagonize STAT5
, but this is unlikely because we did not observe a reduction in STAT5
phosphorylation in SOCS1-deficient Tregs, instead SOCS1-deficient Tregs expanded well due to stronger IL-2/STAT5 activity .
van Kleffens et al., "Distinct roles of the phosphatidylinositol 3-kinase and STAT5
pathways in IL-7-mediated development of human thymocyte precursors," Immunity, vol.
While RGE significantly reduced pSTAT3, the level of STAT5
phosphorylation was not increased with RGE treatment.
PM-43I is also being evaluated in other therapeutic settings where the STAT5
and STAT6 pathways are activated, including as a treatment for chronic sinusitis, idiopathic pulmonary fibrosis (IPF) and atopic dermatitis.
The specific SS, PRL receptor, JAK2, STAT5
, DGAT1, as well as GAPDH primers (Table I) were designed and synthesized by Sangon Biotech (Shanghai, China).
The LIG_SH2_STAT5 motifs matched with amino acid residues YTER (296-299), a functional residue of STAT5
Src Homology 2 (SH2) domain binding motif in the cytosol.
Conway-Campbell et al showed that GHR prolongs STAT5
activation based on its nuclear localization.
Rosso et al., "Interleukin-3 promotes expansion of hemopoietic-derived CD45+ angiogenic cells and their arterial commitment via STAT5
activation," Blood, vol.