STAT5A

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STAT5A

A gene on chromosome 17q11.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT5A protein product is activated by and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin and various growth hormones.

Molecular pathology
STAT5A activation in myeloma and lymphoma and TEL/JAK2 gene fusion is essential for tumourigenesis.
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However, the abundance of hepatic JAK2 and STAT5 proteins are almost invariant during the periparturient period (unpublished data).
Expression of STAT5 protein was significantly higher in BP patients (131.37 [+ or -] 2.55) and DH patients (129.34 [+ or -] 1.37) as compared to the control group (123.48 [+ or -] 1.13; p < 0.05).
SOCS-3 does so by binding to the membrane proximal tyrosine residues recognized by STAT5 whereas CIS/SOCS-2 binds to more distal tyrosine residues (Krebs and Hilton, 2000; Krebs and Hilton, 2001).
In mouse studies it has been reported that the effect of FICZ on Th17 cell differentiation was associated with a reduction in Stat5 phosphorylation [29].
STAT1 may antagonize STAT5, but this is unlikely because we did not observe a reduction in STAT5 phosphorylation in SOCS1-deficient Tregs, instead SOCS1-deficient Tregs expanded well due to stronger IL-2/STAT5 activity [73].
van Kleffens et al., "Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors," Immunity, vol.
While RGE significantly reduced pSTAT3, the level of STAT5 phosphorylation was not increased with RGE treatment.
PM-43I is also being evaluated in other therapeutic settings where the STAT5 and STAT6 pathways are activated, including as a treatment for chronic sinusitis, idiopathic pulmonary fibrosis (IPF) and atopic dermatitis.
The specific SS, PRL receptor, JAK2, STAT5, DGAT1, as well as GAPDH primers (Table I) were designed and synthesized by Sangon Biotech (Shanghai, China).
The LIG_SH2_STAT5 motifs matched with amino acid residues YTER (296-299), a functional residue of STAT5 Src Homology 2 (SH2) domain binding motif in the cytosol.
Conway-Campbell et al showed that GHR prolongs STAT5 activation based on its nuclear localization.
Rosso et al., "Interleukin-3 promotes expansion of hemopoietic-derived CD45+ angiogenic cells and their arterial commitment via STAT5 activation," Blood, vol.