STAT4

A gene on chromosome 17q21.31 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors, including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. The STAT4 protein product mediates responses to IL12 in lymphocytes, and regulates the differentiation of T helper cells.

References in periodicals archive ?

El Sharkawy added, "We found that patients with the risk genetic variation had lower expression of STAT4 in their liver and immune cells, reducing their immune response against hepatitis B and their production of interferon gamma, a protein responsible for moderating fibrosis."

Genetic factors may increase liver damage risk in chronic hepatitis B patients

Rezaei, "Association of stat4 gene single nucleotide polymorphisms with iranian juvenile-onset systemic lupus erythematosus patients," The Turkish Journal of Pediatrics, vol.

Neuropsychiatrie Involvement in Juvenile-Onset Systemic Lupus Erythematosus

PSA: polysaccharide A; ASF: altered Schaedler flora; SCFA: short-chain fatty acids; SFB: segmented filamentous bacteria; APCS: antigen-presenting cells; TLR: Toll-like receptor; TH0, 1, 2, and 17 cells: T helper 0, 1,2, and 17 cells; Treg: regulatory T cell; SAA: serum amyloid A; MAPK: mitogen-activated protein kinase; JNK: c-Jun N-terminal kinase; ERK: extracellular signal-regulated kinase; NF-[kappa]B: nuclear factor kappa B; STAT4 and 6: signal transducer and activator of transcription 4 and 6; MHC: major histocompatibility complex; eNOS: endothelial nitric oxide synthase; VEGFR2: vascular endothelial growth factor receptor 2; Jak: Janus kinase; Tyk: tyrosine kinase; CREB: cAMP-response element binding protein; CRTC2: CREB-regulated transcription coactivator 2.

Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes

And also, the IL-12R01 and STAT4 protein expression significantly decreased (Figure 7(b)).

Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis

Marquez et al., "Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases," Arthritis & Rheumatism, vol.

Extrahepatic Autoimmune Diseases in Patients with Autoimmune Liver Diseases: A Phenomenon Neglected by Gastroenterologists

Caption: Figure 4: Potential binding sites for transcription factors of 1R, 2R, and 3R tandem repeat elements of the XRCC5 VNTR: XBP-1 =X-box binding protein 1; TFII-I = transcription factor II-I; STAT4 = signal transducer and activator of transcription 4; c- Ets-1 = c-E-twenty-six-1; E2F-1=E2F transcription factor 1; GR-beta = glucocorticoid receptor-beta; GCF = GC factor; NF-kappaB = nuclear factor- kappaB; RelA = v-rel avian reticuloendotheliosis viral oncogene homolog A.

XRCC5 VNTR, XRCC6 -61C>G, and XRCC7 6721G>T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case-Control and In Silico Studies

Both undifferentiated mADSCs and cADSCs expressed [beta]-catenin, [beta]-catenin pS45, Akt (pS473), and Stat4 phosphorylation and only mADSCs expressed Stat5 phosphorylation.

Single-Cell Phosphospecific Flow Cytometric Analysis of Canine and Murine Adipose-Derived Stem Cells

IL-12 activates a series of phosphorylation events which permit STAT4 molecules to dimerize and translocate to the nucleus, upregulating a proinflammatory cascade.

Cytokines as Biomarkers and Their Respective Clinical Cutoff Levels

They can also directly interact with gene expression factors and cell signaling involved in cytokine secretion, such as activator protein 1 (AP-1) [37] and signal transducer and activator of transcription 4 (STAT4) [38].

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory Ml to Anti-Inflammatory M2 State

STAT1, STAT2, STAT3, STAT4, STAT5, and STAT6 are the main members of the STAT family [12, 13].

Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells

Various genes have been demonstrated to be relevant to different types of uveitis, comprising HLA-B27, HLA-A29, HLA-B51, HLA-DR4, IL-10, STaT4, STAT3, and UBAC2 [4-6] which suggested genetic factors are involved in the occurrence and development of uveitis.

The Association of Chemokine Gene Polymorphisms with VKH and Behcet's Disease in a Chinese Han Population

During the course of these studies, >50 commonly occurring single-nucleotide polymorphisms (SNPs) were found to be associated with SLE, including human leukocyte antigen (HLA) regions HLA-DRB1-HLA-DQA1,[sup][5] HLA-DQB1-HLA-DQA2,[sup][6] and HLA-DQB2,[sup][6] as well as non-HLA genes (RasGRP3,[sup][5] STAT4,[sup][7] IRF5-TNPO3,[sup][5] ETS1,[sup][8] IKZF1,[sup][5] and TNFAIP3[sup][7]).

Association Study of a Proliferation-inducing Ligand, Spermatogenesis Associated 8, Platelet-derived Growth Factor Receptor-alpha, and POLB Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

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