STAT4


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STAT4

A gene on chromosome 17q21.31 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors, including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. The STAT4 protein product mediates responses to IL12 in lymphocytes, and regulates the differentiation of T helper cells.
References in periodicals archive ?
The rs7574865 and rs10181656 SNPs in the third intron of the STAT4 gene were amplified by polymerase chain reaction (PCR), and the 5'-TTATGGAAAATTACATGAGTGTG-3' and 5'-GCAAATCTTTGTAAAAAGTCAA-3' primers were used to generate a region of 156 bp in the STAT4 gene that could be used in the subsequent genotyping reactions of the rs7574865 polymorphism.
The genotyping of the STAT4 rs7574865 and rs10181656 SNPs was performed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
We've known for some time that STAT4 is a 'gene switch,' meaning it is one of the genes that regulates or 'turns on' immune cells.
Specifically, we've found that STAT4 appears to be involved in insulin resistance as well as the development of atherosclerosis," adds Elena V.
A variant allele of STAT4 is associated with increased risks of both RA and systemic lupus erythematosus (N.
Genetic variation in STAT4 predicts response to interferon-alpha therapy for hepatitis B e antigen-positive chronic hepatitis B.
High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.
16 Moreover, IFN-alpha can inhibit production of IL-12, a potent activator of STAT4 and IFN-gamma production17 which again stresses the importance of IFN-gamma supplementation in anti-HCV regimens.
and Sweden defined a SNP haplotype in the third intron of STAT4 with strong statistical evidence of association with RA (OR = 1.
29) Using immunohistochemistry, they could show that the antiinflammatory STAT6 signalling pathway is expressed mainly by oligodendrocytes, whereas the pro-inflammatory transcription factor STAT4 is expressed by microglia.
Other signals, including STAT2 (Tyr689), STAT4 (Tyr693), STAT5 (Tyr694), and STAT6 (Tyr641) were all negative during stimulation by IL-27, IFN-a, or IL-17 [Figure 2]c and d.
STAT4 is a transcription factor that transmits cytokine signals such as interleukin-12, interleukin-23 and type I interferone in T cells and monocytes leading to the production of interferon-[gamma] and interleukin-17; T-helper type 1 and T-helper type 17 differentiation; and monocyte activation.