STAT4


Also found in: Acronyms, Wikipedia.

STAT4

A gene on chromosome 17q21.31 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors, including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. The STAT4 protein product mediates responses to IL12 in lymphocytes, and regulates the differentiation of T helper cells.
References in periodicals archive ?
In our previous study regarding the current advances in the genetic basis of RA, we observed that many studies had investigated the association between RA and the STAT4 gene, and these had confirmed the results across two major ethnic groups.
In this study, we investigated the association betwen the candidate gene STAT4 and RA in a Turkish population for the first time.
However, additional polymorphisms exist in the STAT4 gene that might contribute to the susceptibility or activity of RA.
The obtained data from this study demonstrates that the rs7574865 and rs10181656 polymorphisms in the STAT4 gene are not associated with susceptibility to RA in Turkish population.
Association between polymorphism in STAT4 gene and risk of rheumatoid arthritis: a meta-analysis.
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
Association of STAT4 with rheumatoid arthritis in the Korean population.
Association of STAT4 with rheumatoid arthritis: a replication study in three European populations.
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians.
Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population.
Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.
Influence of TRAF1/C5 and STAT4 genes polymorphisms on susceptibility and severity of rheumatoid arthritis in Egyptian population.