STAT3


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STAT3

A gene on chromosome 17q21.31 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors, including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. The STAT3 protein product mediates expression of various genes in response to cell stimuli, and thus plays a key role in cell growth and apoptosis. GTPase Rac1 binds and upregulates STAT3; PIAS3 inhibits it.
References in periodicals archive ?
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med 2008; 205(7): 1551-7.
"We knew something was very wrong and at two years, fortunately, he was offered a DNA test and it was then we found out he had a STAT3 gene mutation.
Because Stat3 regulates many cellular processes, the scientists combed through genes expressed during muscle growth to find additional proteins regulated by Stat3 that might serve as more specific targets.
Antibodies specific to p-STAT3, STAT3, COX-2, MMP-2, MMP-9 were purchased from Cell Signaling Technology (Shanghai, China) while antibodies specific to E-cadherin, N-cadherin and Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were purchased from Proteintech (Wuhan, Hubei, China).
KCs were seeded into sterilized 96-well plastic plates made of polystyrene and transfected with 100 nmol/L STAT3 siRNA (LUS group) or siRNA-NC carried by Lipofectamine 3000 associated with SonoVue microbubbles and then irradiated by the probe of ultrasonic transfer apparatus through ultrasound couplant (Yalian, China) from the bottom of the plates.
Additionally, IL-17 can directly stimulate collagen production in HSCs through STAT3 activation [31], and STAT3 is also suggested to play a protective role in the liver by enhancing hepatocyte regeneration [32].
Consistent with previous studies, we found that infusion of MSCs activated STAT3 signaling, exhibiting increased expression of p-STAT3 at 24 h (Figure 5(c)).
With a high suspicion of AD-HIES, mutation analysis of STAT3 gene was sent which detected a novel pathogenic mutation, C.1388 T> A (pVal463Glu) at DNA-binding domain of STAT3 gene.
We identified the correct LC concentrations as the lower concentrations that activated STAT3 signaling.
IL6 stimulates survival, proliferation, and progression to cancer of intestinal epithelial cells via activation of signal transducers and activators of transcription 3 (STAT3), eventually inducing the expression of SCOS3 [47].
STAT3 signaling regulates various biological processes, such as cell growth, survival, differentiation, and apoptosis [7].