The protein level of IRF7 was correlated only with that of STAT2
in the tumor tissue but with those of molecules other than STAT2
and IFNAR1 in the normal tissue.
Production of IFN-[beta] causes activation of interferon stimulated gene factor 3 (ISGF3), a heterotrimer composed of signal transduction and activator of transcription 1 (Stat1), Stat2
, and IRF9 to induce production of T helper type 1 (Th1) chemokines such as CXCL9, CXCL10, and CXCL11.
Similarly, experimental studies have confirmed that ZIKV NS5 is required for the proteasomal degradation of the STAT2
in humans [92, 93].
IL-28A upregulates the expression of STAT1 and STAT2
Formation of the ISGF3 complex and its migration to the nucleus requires tyrosine phosphorylation of STAT1 and STAT2
proteins by JAK1.
Stoner et al., "STAT2
is an essential adaptor in USP18-mediated suppression of type I interferon signaling," Nature Structural & Molecular Biology, vol.
In the NCGS dataset, 6 type I interferon inducible genes (IFIG) were upregulated (IFNA17, IRF5, IRF3, STAT2
, STAT1, and LY9), thus indicating the presence of an IFN type I signature, typically associated with autoimmune disease such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn's disease, and Sjogren syndrome [19-25].
Four types of JAK (JAK1, JAK2, JAK3, and Tyk2) and seven types of STAT (STAT1, STAT2
, STAT3, STAT4, STAT5a, STAT5b, and STAT6) proteins exist.
Other signals, including STAT2
(Tyr689), STAT4 (Tyr693), STAT5 (Tyr694), and STAT6 (Tyr641) were all negative during stimulation by IL-27, IFN-a, or IL-17 [Figure 2]c and d.
ATF6 AACS 1.198925 MYCN AAGAB 1.031 DDIT3 AAMP 1.237609 RREB1 AAMP 1.005331 STAT2
AAMP 1.085082 STAT3 AAMP 1.268363 STAT4 AAMP 1.067587 CBFB AASS 1.027421 NFYA AASS 1.028667 ARNT AATF 1.000478 TABLE 2: Top 10 TFs in differentially regulatory network.
mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.
Secreted type I IFNs bind to the ubiquitously expressed IFNA receptor (IFNAR) on the same cells as well as on neighboring cells and initiate a signaling cascade finally leading to the activation and phosphorylation of the signal transducers and activators of transcription (STAT) STAT1 and STAT2
. This enables complex formation with IRF9 to build the trimeric transcription factor ISGF3 which binds to the IFN-stimulated response element (ISRE), present in the upstream region of ISGs.