STAT2


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STAT2

A gene on chromosome 12q13.3 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT2 protein product responds to interferon by forming a complex with STAT1 and IFN regulatory factor family protein p48 (SGF3G), acting as a transactivator without directly binding DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) interacts with STAT2, which is thought to play a role in blocking IFN-alpha response by adenovirus.
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IL-28A upregulates the expression of STAT1 and STAT2
Treatment with 40 [micro]g/kg IL-28A dramatically increased the protein levels of STAT1 and STAT2 in the heart tissues of mice 4 days after CVB3 infection (Fig.
It was well documented that activation of STAT1 and STAT2 was essential for antiviral effect of IFNs.
Formation of the ISGF3 complex and its migration to the nucleus requires tyrosine phosphorylation of STAT1 and STAT2 proteins by JAK1.
All IFN[alpha]s and IFN[beta] bind to the same receptor and as a result, the cytoplasmic kinases JAK1 and TYK2 become activated and phosphorylate the STAT1 and STAT2 molecules.