STAT2


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STAT2

A gene on chromosome 12q13.3 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT2 protein product responds to interferon by forming a complex with STAT1 and IFN regulatory factor family protein p48 (SGF3G), acting as a transactivator without directly binding DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) interacts with STAT2, which is thought to play a role in blocking IFN-alpha response by adenovirus.
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The protein level of IRF7 was correlated only with that of STAT2 in the tumor tissue but with those of molecules other than STAT2 and IFNAR1 in the normal tissue.
Production of IFN-[beta] causes activation of interferon stimulated gene factor 3 (ISGF3), a heterotrimer composed of signal transduction and activator of transcription 1 (Stat1), Stat2, and IRF9 to induce production of T helper type 1 (Th1) chemokines such as CXCL9, CXCL10, and CXCL11.
Similarly, experimental studies have confirmed that ZIKV NS5 is required for the proteasomal degradation of the STAT2 in humans [92, 93].
Formation of the ISGF3 complex and its migration to the nucleus requires tyrosine phosphorylation of STAT1 and STAT2 proteins by JAK1.
Stoner et al., "STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling," Nature Structural & Molecular Biology, vol.
In the NCGS dataset, 6 type I interferon inducible genes (IFIG) were upregulated (IFNA17, IRF5, IRF3, STAT2, STAT1, and LY9), thus indicating the presence of an IFN type I signature, typically associated with autoimmune disease such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn's disease, and Sjogren syndrome [19-25].
Four types of JAK (JAK1, JAK2, JAK3, and Tyk2) and seven types of STAT (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6) proteins exist.
Other signals, including STAT2 (Tyr689), STAT4 (Tyr693), STAT5 (Tyr694), and STAT6 (Tyr641) were all negative during stimulation by IL-27, IFN-a, or IL-17 [Figure 2]c and d.
ATF6 AACS 1.198925 MYCN AAGAB 1.031 DDIT3 AAMP 1.237609 RREB1 AAMP 1.005331 STAT2 AAMP 1.085082 STAT3 AAMP 1.268363 STAT4 AAMP 1.067587 CBFB AASS 1.027421 NFYA AASS 1.028667 ARNT AATF 1.000478 TABLE 2: Top 10 TFs in differentially regulatory network.
STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.
Secreted type I IFNs bind to the ubiquitously expressed IFNA receptor (IFNAR) on the same cells as well as on neighboring cells and initiate a signaling cascade finally leading to the activation and phosphorylation of the signal transducers and activators of transcription (STAT) STAT1 and STAT2. This enables complex formation with IRF9 to build the trimeric transcription factor ISGF3 which binds to the IFN-stimulated response element (ISRE), present in the upstream region of ISGs.