STAT1


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STAT1

A gene on chromosome 2q32.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT1 protein product is activated by IFN-alpha, IFN-gamma, EGF, PDGF and IL6; it mediates the expression of various genes, which is important for cell viability in response to different cell stimuli and pathogens.
References in periodicals archive ?
Chemotherapy eradicated the host's bone marrow - the source of disease-fighting blood cell-and in these patients the damaging STAT1 mutation.
The STAT1 pathway is one of the signal transduction pathways that controls T-bet expression (Afkarian et al.
Western blot analysis was performed as described in the literature to evaluate the expressions of STAT1 and STAT2.
STATI Progressive dysregulation of STAT1 in prostate cancer cells contributes to prostate tumor growth (55).
23) IL-27 activates STAT1 and STAT3 and enhances antitumor cellular and humoral immunity.
A new study led by Professor Uwe Vinkemeier from the University of Nottingham, centered on STAT1, a protein that can bind DNA and hence plays a vital role in regulating genes in the body.
The compound increased IFN-[gamma] signaling by inhibiting STAT1 (signal transducer and activator of transcription 1 protein) dephosphorylation and prolonging STAT1 activation through specific inhibition of T-cell protein tyrosine phosphatase (TCPTP), an important tyrosine phosphatase for STAT1 dephosphorylation [140].
TEL/PDGFbetaR fusion protein activates STAT1 and STAT5: a common mechanism for transformation by tyrosine kinase fusion proteins.
Among the topics are the regulation of transcriptional factor function by targeted protein degradation, assessing sequence-specific DNA binding and transcriptional activity of STAT1 translation factor, detecting modified factors at target gene promoters in the post-translational control of ETS transcriptional factors, and the flow cytometry analysis of transcriptional factors in T lymphocytes.
Levels of phosphorylated STAT1 increased 12 and 24 hr after PH in vehicle-treated mice, whereas phosphorylated STAT1 was not detected in TCDD-treated mice at any time point tested.
E6 binds to TYK2 preventing binding to the cytoplasmic portion of the IFN receptor inhibiting phosphorylation of TYK2, STAT1, STAT2 impairing JAK STAT activation and therefore inhibiting specifically IFN-[alpha] mediated signalling (64).
It has been demonstrated that Th1 differentiation is influenced by STAT1, STAT4 and T-bet and Th2 differentiation is influenced by STAT6, c-maf and GATA-3.