CCL20

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CCL20

A gene on chromosome 2q33-q37 that encodes a chemotactic factor that attracts lymphocytes and neutrophils, but not monocytes. CCL20 inhibits proliferation of myeloid stem cells in colony formation assays, and may be involved in proliferation and activity of mucosal lymphoid tissues (e.g., BALT, MALT, SALT) by attracting lymphocytes and dendritic cells towards epithelial cells.
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To the Editor: Several clones of extended-spectrum (3-lactamase (ESBL)-producing extraintestinal pathogenic Escherichia coli (ExPEC) have globally expanded their distribution, including multilocus sequence types (MLSTs) ST38, ST131, ST405, and ST648 (1).
EAEC ST38, the most common (55%) ST, was significantly associated with extraintestinal sites in the subset of 140 human isolates (Fisher exact test, p<0.
coli entries in June 2013, ST38 is predominantly associated with urinary tract infections, but in-house MLST studies at the Gastrointestinal Bacteria Reference Unit, Public Health England, have shown that ST38 is a successful EAEC group.
Because the EAEC ST38 strain had 4-7 ExPEC-associated virulence factors, we suggest that, on the basis of epidemiologic, microbiological, and molecular characteristics, the EAEC ST38 described in this study should be considered an ExPEC associated with uropathogenic infections.
Isolates were of described sequence types (STs) (ST131 [12 isolates], ST38 [10], ST405 [3], and ST10 [1]), and of previously undescribed STs (designated ST2253 [1 isolate] and ST2967 [6 isolates]) (Table).
coli indicated 4 known STs; ST10, ST38, ST131, and ST405, all very common in the material from Canada (8), and major STs responsible for CTX-M dissemination worldwide (1).
coli 12 14 -- 1 ST38 (ST2253) ([double dagger]) 11 14 -- -- ST131 (ST10) ([section]) 5 -- -- 19 ST2967 ([paragraph]) 3 27 -- -- ST405 1 15 -- -- ST131 1 -- -- 1 ST2967 ([paragraph]) K.
The most prevalent STs were: ST38 (12%; n = 17), ST10 (7%; n = 10), and ST131 (4%; n = 9).
Emergence of OXA-48-producing Escherichia coli clone ST38 in France.
However, multilocus sequence typing identified 2 clonal complexes: ST38 (3 strains) and ST10 (1 strain).
The 3 strains in clonal complex ST38 belonged to the potentially virulent phylogenetic group D; the other 2 belonged to group B2 (Table 2).
Gene aatA was detected in the 5 strains, whereas aap, aggR, and aggA had positive amplification for only 2 of the strains belonging to ST38.