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This study aimed to evaluate short-term preoperative octreotide (OCT) use in TSHoma patients and to investigate SSTR2 and SSTR5 expression and observe structural changes in tumor tissue.
SSTR have five subtypes (SSTR1–5) – mostly SSTR2 and SSTR5 – those are widely expressed in both normal and neoplastic human pituitary cells.
To probe into the underlying mechanisms of OCT in TSHoma treatment, we assessed the outcomes of short-term preoperative OCT treatment for patients with TSHoma and investigated SSTR2 and SSTR5 expression by immunohistochemistry (IHC) in tumor specimens, as well as their subcellular characteristics at electron microscopy, aiming at providing evidence for TSHoma medical therapy.
The primary SSTR2 antibody was ab13120 (1:100), and the primary SSTR5 antibody was ab13121 (1:100; Abcam, Cambridge, UK).
Wilcoxon rank-sum testwas used to investigate TSH suppression rate and SSTR5 expression.
The SSTR5 has been found to preferentially bind SS-28 rather than SS-14 (Patel et al.
Este peptido se une con alta afinidad a los receptores de somatostatina de tipos SSTR2 y SSTR5.
Our recent experiments have localised SSTR2, SSTR3 and SSTR5 on the surface of the egg and worm stages of the parasite in host liver and ileum using immunohistochemistry, dot blot and western blotting techniques (Fig.
These chosen sequential epitopes of human and mouse SSTRs (against which the antibodies were raised and screened on parasite sections) were: SSTR2A (RSDSKQDKSRLNETTC), SSTR3 (TAGDKASTLSHL) and SSTR5 (KSGRPQTTLPTRSC).
The sequential epitopes of human and mouse SSTRs (against which the antibodies were raised and used for immunohistochemistry on parasite sections)--SSTR2A (RSDSKQDKSRLNETTC) showed identical stretch of five amino acid residues, SSTR3 (TAGDKASTLSHL) showed identical stretch of ten amino acid residues while sequential epitopes of human and mouse SSTR5 (KSGRPQTTLPTRSC) showed three and four consecutive identical amino acid residues with a non-identical residue in between on comparison with the GPCR family sequence pattern.
The SSTR2A receptor protein is found in the human GI lymphatic and nervous components, SSTR3 mRNA is identified in intestinal smooth muscle cells pointing to its role in regulating gut motility, SSTR5 has been reported to play a role in cell proliferation (19).
Upon sequence comparison of human, mouse and rat SSTR2A and SSTR5 amino acid sequences (Swissprot database) with proteins coded for by the S.
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