SSTR5

SSTR5

A gene on chromosome 16p13.3 that encodes a G protein-coupled somatostatin receptor for somatostatin-28 and, to a lesser extent, for somatostatin-14. It is expressed in adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and foetal hypothalamus.
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Signifor LAR has the potential to stimulate both SSTR2 and SSTR5 subtype receptors, which are relevant for inhibition of GH and IGF-1 secretion, making Signifor LAR a more effective treatment for acromegaly compared to other SSAs currently used to treat this disease[sup.
Our recent experiments have localised SSTR2, SSTR3 and SSTR5 on the surface of the egg and worm stages of the parasite in host liver and ileum using immunohistochemistry, dot blot and western blotting techniques (Fig.
These chosen sequential epitopes of human and mouse SSTRs (against which the antibodies were raised and screened on parasite sections) were: SSTR2A (RSDSKQDKSRLNETTC), SSTR3 (TAGDKASTLSHL) and SSTR5 (KSGRPQTTLPTRSC).
The sequential epitopes of human and mouse SSTRs (against which the antibodies were raised and used for immunohistochemistry on parasite sections)--SSTR2A (RSDSKQDKSRLNETTC) showed identical stretch of five amino acid residues, SSTR3 (TAGDKASTLSHL) showed identical stretch of ten amino acid residues while sequential epitopes of human and mouse SSTR5 (KSGRPQTTLPTRSC) showed three and four consecutive identical amino acid residues with a non-identical residue in between on comparison with the GPCR family sequence pattern.
The SSTR2A receptor protein is found in the human GI lymphatic and nervous components, SSTR3 mRNA is identified in intestinal smooth muscle cells pointing to its role in regulating gut motility, SSTR5 has been reported to play a role in cell proliferation (19).
Upon sequence comparison of human, mouse and rat SSTR2A and SSTR5 amino acid sequences (Swissprot database) with proteins coded for by the S.
In the present study we also noted an association between somatostatin therapy and down-regulation of the SSTR2A and SSTR5 like GPCRs on the surface of the adult S.