SSTR3

SSTR3

A gene on chromosome 22q13.1 that encodes a G protein-coupled somatostatin receptor for somatostatin-14 and -28. It is expressed in the brain, pituitary and pancreas.
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Among them, GO:0004888 dominantly contains 33 transcripts encoding signal receptors, and these receptors could be further classified into several subgroups: OXTR, LOC431251 and SSTR3 belong to reproductive hormone receptors; CHRM2, ADRA2B, P2RX4, P2RY2, EDNRB2, GABRB2, GABRG2, LOC428961 and NPFFR2 function as receptors mediating neurotransmitters or neuropeptide; GRIN2B and GRIN3A could modulate the efficiency of synaptic transmission; NTRK1 and NTRK2 belong to the receptor tyrosine kinase (RTK) family, and are involved with neurotrophin (GO:0005030--neurotrophin receptor activity; and GO:0043121--neurotrophin binding) (Table 5).
Our recent experiments have localised SSTR2, SSTR3 and SSTR5 on the surface of the egg and worm stages of the parasite in host liver and ileum using immunohistochemistry, dot blot and western blotting techniques (Fig.
These chosen sequential epitopes of human and mouse SSTRs (against which the antibodies were raised and screened on parasite sections) were: SSTR2A (RSDSKQDKSRLNETTC), SSTR3 (TAGDKASTLSHL) and SSTR5 (KSGRPQTTLPTRSC).
The sequential epitopes of human and mouse SSTRs (against which the antibodies were raised and used for immunohistochemistry on parasite sections)--SSTR2A (RSDSKQDKSRLNETTC) showed identical stretch of five amino acid residues, SSTR3 (TAGDKASTLSHL) showed identical stretch of ten amino acid residues while sequential epitopes of human and mouse SSTR5 (KSGRPQTTLPTRSC) showed three and four consecutive identical amino acid residues with a non-identical residue in between on comparison with the GPCR family sequence pattern.
The SSTR2A receptor protein is found in the human GI lymphatic and nervous components, SSTR3 mRNA is identified in intestinal smooth muscle cells pointing to its role in regulating gut motility, SSTR5 has been reported to play a role in cell proliferation (19).