SSTR2

SSTR2

A gene on chromosome 17q24 that encodes a G protein-coupled somatostatin receptor for somatostatin-14 and -28. It interacts with SHANK1 and is expressed in the brain and kidneys.
References in periodicals archive ?
The company's lead pentarin clinical drug candidate, PEN-221, targets the somatostatin receptor 2 (SSTR2) for treatment of patients with tumors that express SSTR2 including neuroendocrine, small cell lung, and other cancers.
This study aimed to evaluate short-term preoperative octreotide (OCT) use in TSHoma patients and to investigate SSTR2 and SSTR5 expression and observe structural changes in tumor tissue.
SSTR have five subtypes (SSTR1–5) – mostly SSTR2 and SSTR5 – those are widely expressed in both normal and neoplastic human pituitary cells.
To probe into the underlying mechanisms of OCT in TSHoma treatment, we assessed the outcomes of short-term preoperative OCT treatment for patients with TSHoma and investigated SSTR2 and SSTR5 expression by immunohistochemistry (IHC) in tumor specimens, as well as their subcellular characteristics at electron microscopy, aiming at providing evidence for TSHoma medical therapy.
Serial 4-[micro]m-thick sections were cut from formalin-fixed and paraffin-embedded pituitary adenoma tissues and used for histological diagnosis and IHC staining for SSTR2 and SSTR5.
15) El desarrollo de analogos especificos del receptor SSTR2 podria representar un avance en el tratamiento medico.
Este peptido se une con alta afinidad a los receptores de somatostatina de tipos SSTR2 y SSTR5.
The sensitivity is reduced if there is a lack of SSTR2 expression, as is seen in poorly differentiated NETs and insulinomas.
Our recent experiments have localised SSTR2, SSTR3 and SSTR5 on the surface of the egg and worm stages of the parasite in host liver and ileum using immunohistochemistry, dot blot and western blotting techniques (Fig.
Retrieval of SSTR sequences: The sequences of human, mouse and rat SSTR2, 3 and 5 were retrieved from Swiss-Prot (10-12) using the sequence retrieval system 5 (SRS) (Table 1a-c).
mansoni genome database maintained at the European Bioinformatics Institute (EBI) was searched for the presence of sequence(s) of SSTR2, 3 and 5 using tBLASTn (13,14) using default parameters (Table 2).
PEN-221 comprises a highly selective peptide that targets SSTR2 linked to the potent cytotoxic DM1 through a cleavable linker.