68 Ga-DOTATOC is more specific for SSTR-2, however, 68 Ga-DOTANOC has a selectivity for SSTR2
, 3 and 5.
Feokromositomalar ve ekstra adrenal paragangliomalar katekolamin ureten, kromaffin hucre kaynakli tumorler olup, somatostatin tip 2 reseptorlerinin (SSTR2
) yuksek oranda ekspresyonu vardir.
A key design feature of HTL0030310 is its significant selectivity for SSTR5 over SSTR2
. The clinical trial with HTL0030310 is a double-blind, randomised, placebo-controlled first-in-human study in which single ascending subcutaneous doses of HTL0030310 will be administered to healthy male and female adult subjects.
is most predominantly expressed by NETs and is therefore commonly targeted for imaging and endoradiotherapy.
In 1994, Greenman and Melmed analyzed SSTR 3, SSTR4, and SSTR5 in 33 pituitary adenomas and SSTR1 and SSTR2
in 27 pituitary adenomas using RT-PCR, including 2 and 3 ACTH-producing adenomas, respectively.
[SUV.sub.max] of PanNEN was higher than that of GINENs, which was consistent with prior studies [21,22], where the investigators found higher levels of messenger RNA expression of SSTR2
and SSTR5 in pancreatic than in gastrointestinal NENs.
Octreotide: Octreotide, is an eight amino acid, synthetic, long-acting somatostatin analogue that inhibits insulin secretion by binding to somatostatin receptors 2 and 5 (SSTR2
and SSTR5) (110).
This study aimed to evaluate short-term preoperative octreotide (OCT) use in TSHoma patients and to investigate SSTR2
and SSTR5 expression and observe structural changes in tumor tissue.
Duan et al., "Somatostatin receptors SSTR2
and SSTR5 are expressed in the human thoracic duct," Lymphology, vol.
One proposed mechanism for forebrain NE loss in AD is a decrease in somatostatin receptor-2 (SSTR2
) in LC neurons .
His result was SSTR2
(2+), SSTR5 (2+), and mTOR (-).
They found an increased expression of SSTR2
in functioning NETs as compared to nonfunctioning NETs and no association with lymph node metastases at diagnosis, as opposite to our study where there was no statistically significant correlation between SSTR2
expression and presence of syndrome (p = 0.116) but low SSTR2A QS was associated with stage IIB-IV disease at diagnosis .