SSRI


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Related to SSRI: serotonin, SNRI

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

SSRI

(ĕs′ĕs-är-ī′)
n.
Any of a class of drugs, such as fluoxetine or sertraline, that inhibit the reuptake of serotonin by neurons of the central nervous system and are primarily used in the treatment of depression and obsessive compulsive disorder.

SSRI

Selective serotonin re-uptake inhibitor, see there, aka SRI.

SSRI

Abbreviation for selective serotonin reuptake inhibitor.

Selective serotonin reuptake inhibitor (SSRI)

A class of antidepressants that work by blocking the reabsorption of serotonin in the brain, raising the levels of serotonin. SSRIs include Prozac, Zoloft, and Paxil.

SSRI

Abbreviation for selective serotonin reuptake inhibitor.
References in periodicals archive ?
(15,16) The joint statement issued by the Royal Australian and New Zealand College of Psychiatry, the Royal Australian College of GPs and the Royal College of Australian Physicians states that it is important for children and adolescents to continue to have access to SSRIs. Not treating depression is more likely to result in harm than the appropriate use of antidepressants.
There are a number of reasons for the widespread use of SSRI antidepressants by women.
The seven currently marketed SSRIs are frequently prescribed to people diagnosed with major depression or with anxiety ailments such as obsessive-compulsive disorder or social phobia.
SSRIs cause increased amounts of serotonin to remain in a synapse.
"However, I believe that physicians need to be warned about the fact that their patients may well be in the small, vulnerable subpopulation of people whose lives might be endangered by violent reactions to SSRIs."
No significant differences appeared in the impact of SSRI use according to gender for LBMI, height z scores, or VFat.
SSRI use was associated with an increased risk of UGI bleeding in 7-, 14-, and 21day windows before the index event (TABLE2).
Acting on the positive findings of a previous clinical trial that involved the use of SAMe in depressed serotonin-reuptake inhibitor non-responders, Matthew Bambling of the University of Queensland and colleagues compared the effects of adding 15 weeks of high-dose (1,600 mg) and low-dose (800 mg) SAMe supplementation to the regimens of patients using SSRIs who had less-than-optimal treatment response.
This indicates that SSRI exposure "may be" associated with an increased risk of PPHN, but the magnitude of that risk--if present--is smaller than previous studies have reported, Krista F.
The prevalence of metabolic syndrome was 32% among SSRI recipients, versus 45% in those whose PTSD was not treated with SSRIs.
The most frequently used SSRI was citalopram (6.49 prescriptions per 1,000 population), followed by fluoxetine (4.66/1,000) and sertraline (3.93/1,000).
Evidence suggests adding L-methylfolate to selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) when starting pharmacotherapy leads to greater reduction of depressive symptoms in a shorter time compared with SSRI or SNRI monotherapy.