SOCS2

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SOCS2

A gene on chromosome 12q that encodes a member of the suppressor of cytokine-signalling—i.e., STAT-induced STAT inhibitor—family, which are cytokine-inducible negative regulators of cytokine signalling. SOCS2 expression is induced by cytokines (e.g., erythropoietin, CSF2/GM-CSF, IL10 and interferon-gamma), and it provides a negative feedback loop to attenuate cytokine signalling. SOCS2 interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in regulating IGF1R-mediated cell signalling.
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References in periodicals archive ?
A total of 23 differentially expressed genes involved in fatty acid synthesis were identified in this study, including 7 long-chain acyl-CoA synthetases (LACS), ACC1, 4 beta-ketoacyl-ACP synthases (KASs), FAB1, SSI2, FATB, FTM1, and MOD1.
I been in a couple of competitions!' (SSI2: Ukrainian woman trafficked for sex)
Plasmids containing a fragment of the wild-type or the Leiden-mutated form of the factor V gene were made by PCR amplification of wild-type DNA or DNA from a patient with the Leiden mutation, using the primers SSI1 [5'-GGAACAACACCATGATCAGAGCA-3' (positions 1605-1627)] and SSI2 [5'-TA000AGGAGACCTAACATGTTC-3' (positions 1870-1892)].