SOCS1

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SOCS1

A gene on chromosome 16p13.13 that encodes a member of the suppressor of cytokine-signalling—i.e., STAT-induced STAT inhibitor—family, which are cytokine-inducible negative regulators of cytokine signalling. SOCS1 expression is induced by cytokines (e.g., IL2, IL3, erythropoietin, CSF2/GM-CSF and interferon-gamma), and it provides a negative feedback loop to attenuate cytokine signalling.
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Discrimination between use and abuse: abuse and dependence using ANOVA and Receiver Operating Characteristic (ROC) analysis ASSIST Domain ROC ROC ROC (AUC) Sensitivity Specificity (%) (%) Global Continuum of Risk Use/abuse 0.82 92 66 Abuse/depend (2) 0.70 81 60 SSI1 score for Alcohol Use/abuse 0.76 74 75 Abuse/depend (2) 0.62 65 63 ASSIST Domain ASSIST ANOVA Cut-off Mean diff.
Plasmids containing a fragment of the wild-type or the Leiden-mutated form of the factor V gene were made by PCR amplification of wild-type DNA or DNA from a patient with the Leiden mutation, using the primers SSI1 [5'-GGAACAACACCATGATCAGAGCA-3' (positions 1605-1627)] and SSI2 [5'-TA000AGGAGACCTAACATGTTC-3' (positions 1870-1892)].