SOX10

(redirected from SRY-related HMG-box gene 10)

SOX10

Notation for a gene for Waardenburg type 4 syndrome.
Farlex Partner Medical Dictionary © Farlex 2012

SOX10

A gene on chromosome 22q13.1 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX10 may act as a transcription activator after forming a complex with other proteins; it acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development.

Molecular pathology
SOX10 mutations cause Waardenburg-Shah and Waardenburg-Hirschsprung disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
(1) During the development of glial cells, oligodendrocytes differentiate from oligodendrocyte precursor cells (OPCs) through the involvement of special intrinsic transcription factors such as oligodendrocyte transcription factor 2 (OLIG2), Nkx-2.2, and Sry-related HMg-Box gene 10 (SOX10); in addition, some inhibitory signaling pathways including Wnt and Notch, which are the result of their final performance, play critical roles in OPC differentiation into oligodendrocytes and the myelination process.
Sry-related HMG-Box gene 10 (SOX10) protein is a human transcription factor important for neural crest, peripheral nervous system, and melanocytic cell development.
Sry-related HMG-Box gene 10 (SOX10) in normal tissues.
Sry-related HMG-Box gene 10 (SOX10) expression in spindle cell/desmoplastic/sarcomatoid melanomas.