SRY gene


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Related to SRY gene: Swyer syndrome, SOX9

SRY gene

(ĕs′är-wī′)
n.
A gene for maleness found on the Y chromosome. It has a key role in development of the testes and determination of sex.

SRY gene

One of the few genes on the Y chromosome. This gene promotes the development of the testes in males.
References in periodicals archive ?
And it is the SRY gene that sparks the genetic program leading to the formation of testes and the production of fetal testosterone.
However, the sry gene could not be detected in lung tissue of healthy mice or organs other than lung in BLM-treated mice that received MSCs.
None of the platypus Y chromosomes contains an SRY gene.
In addition, PCR examination (Figures VIII- IX) of sry gene expression in the ovarian tissues obtained from Group II presented further evidence of stem cell incorporation into the ovarian structure.
The Sry gene encodes a transcription factor that is a member of the HMG-box family of DNA binding proteins.
Using a new proprietary method for isolation of Tr-DNA, Xenomics' scientists successfully detected sequences of a single copy Y chromosome-specific SRY gene in urine of women pregnant with male fetuses from the 6th week of pregnancy.
The researchers hypothesize that paternal exposures prior to conception might affect expression of the SRY gene on the Y chromosome.
For the determination of fetal sex by the SRY gene of the Y chromosome all three replicate amplifications of a sample had to be either positive or negative, otherwise the sample was undetermined.
Moreover, in males, a single gene on the Y chromosome, known as SRY, is critical for testis development, and translocation of the SRY gene to the X chromosome explains testis development in 90% of XX males.
Prof Graves believes it could take ten million years for the mammalian Y chromosome to lose its 45 genes, one of which - the SRY gene - induces the development of testes and the release of male hormones.
That stretch of mouse DNA, which they dubbed Sry, resembles the human SRY gene.