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(3,6) Yousem (5) described the same phenomenon, referring to it as RBILD with fibrosis, in patients originally diagnosed with nonspecific interstitial pneumonia (NSIP), suggesting that in a subset of patients SRIF may account for a syndrome of mild restrictive lung disease.
Histologically, SRIF is characterized by alveolar septal thickening by a distinctive pattern of paucicellular, dense, eosinophilic collagen that has a ropy or waxy quality, and is accompanied by emphysematous changes and RB (discussed below).
Additionally, with rare exceptions, patients discovered to have SRIF do not suffer from progressive interstitial lung disease.
Although SRIF is morphologically distinct, separating SRIF from UIP and NSIP can be difficult on small biopsies and may require incorporation of ancillary data.
Distinguishing SRIF and NSIP can be even more challenging, and upon retrospective review, some cases diagnosed as NSIP have later been recategorized as SRIF.
The grant is fourth largest given out by SRIF from a total fund of more than pounds 1 billion.
'This major award from SRIF is wonderful news and reinforces independent recognition of the university's extremely high standard of research and development work,' he said.
SRIF is a new Government initiative, addressing the bigger research picture by channelling more funding towards essential building infrastructure as well as state-of-the-art equipment.
It is hoped the SRIF grant will provide a solid platform on which the university can build leading and world class research projects to address priority areas regionally, nationally and internationally.
The new pounds 1 billion initiative, to be known as the Science Research Investment Fund (SRIF), brings together three funding bodies - the Wellcome Trust, the Office of Science and Technology and the Higher Education Funding Council for England - which had previously collaborated on the pounds 750 million Joint Infrastructure Fund (JIF).
'The new SRIF comes in recognition of the excellence of the proposals received by JIF and is a joint commitment ...
The new initiative, to be known as the Science Research Investment Fund (SRIF), brings together three funding bodies - the Wellcome Trust, the Office of Science and Technology and the Higher Education Funding Council for England - which had previously collaborated on the pounds 750 million Joint Infrastructure Fund (JIF).
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