SREBF2

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SREBF2

A gene on chromosome 22q13 that encodes a ubiquitously expressed transcription factor with a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain, which controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The cognate gene product is required for lipid homeostasis: it regulates transcription of the LDL receptor gene, cholesterol and the fatty acid synthesis pathway.
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References in periodicals archive ?
The result turned out that compared to TSH, ARRB1 -KD cells treated with SC79 showed an increased level of mature SREBP2 and decreased level of CYP7A1.
Deficiencies in ARRBs led to a decreased level of TSH-stimulated AKT phosphorylation and a subsequent reduction in mature SREBP2. The AKT activator SC79, other than TSH, could upregulate AKT phosphorylation independent of TSHR and ARRBs, and SC79 treatment subsequently increased mature SREBP2 levels.
When compared to the smooth muscle cells from healthy adults, it was found that the cells from patients with Alzheimer's disease had about five times as much myocardin and four times as much SRF, about five times as much SREBP2, and about 60 percent less LRP-1.
A subsequent literature search turned up findings that the molecules might affect SREBP2, and thus the team could move forward and put the whole picture together.
Haumont et al., "Expression of miR33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation," Journal of Biological Chemistry, vol.
miR-27a RXRa, ABCA1, FASN, RXRa, ABCA1, FASN, SREBP1, SREBP2, SREBP1, SREBP2, PPAR[alpha], PPAR[alpha], PPAR[gamma] ApoA1, PPAR[gamma] ApoA1, ApoB100, ApoE3 ApoB100, ApoE3 miR-27b PPAR[gamma], ANGPTL3, miR-27b is predicted to NDST1, GPAM target 27 mRNAs involved in lipid metabolism; targets in the second column have already been validated.
Horiguchi et al., "MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo," Proceedings of the National Academy of Sciences of the United States of America, vol.
Transcriptional regulation of hepatic LDLr expression is classically regulated through sterol regulatory element binding protein 2 (SREBP2), signaled through cellular cholesterol [12].
Nuclear and cytoplasmic enriched extracts for immunoblot analyses of SrEBP1c (Novus Biologicals, NB600-582), SREBP2 (Abcam, ab30682), PCSK9 (Abcam, ab31762), and [beta]-actin (Cell Signaling, 8H10D10) were prepared according to our previously published procedures [27].
Strong induction of PCSK9 gene expression through HNF1a and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters.
SREBPs play a central role in cellular lipogenesis and lipid homeostasis by controlling the synthesis of fatty acids, triacylglycerols, and cholesterol [30] and comprise three main proteins, termed SREBP-1a, SREBP-1c, and SREBP-2, that are encoded by two genes: SREBP1 and SREBP2. While SREBP-1a and SREBP-1c control the fatty acid pathways, SREBP-2 regulates the cholesterol biosynthetic pathway.
It could result from increased intrahepatic cholesterol concentrations and subsequently reduced SREBP2 (sterol regulatory element-binding protein 2) activity on PCSK9 gene transcription (5, 17).