SREBF2

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SREBF2

A gene on chromosome 22q13 that encodes a ubiquitously expressed transcription factor with a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain, which controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The cognate gene product is required for lipid homeostasis: it regulates transcription of the LDL receptor gene, cholesterol and the fatty acid synthesis pathway.
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When compared to the smooth muscle cells from healthy adults, it was found that the cells from patients with Alzheimer's disease had about five times as much myocardin and four times as much SRF, about five times as much SREBP2, and about 60 percent less LRP-1.
SREBPs play a central role in cellular lipogenesis and lipid homeostasis by controlling the synthesis of fatty acids, triacylglycerols, and cholesterol [30] and comprise three main proteins, termed SREBP-1a, SREBP-1c, and SREBP-2, that are encoded by two genes: SREBP1 and SREBP2.
It could result from increased intrahepatic cholesterol concentrations and subsequently reduced SREBP2 (sterol regulatory element-binding protein 2) activity on PCSK9 gene transcription (5, 17).