Statins downregulate the expression of crucial genes for adipocyte differentiation including C/EBPa, PPAR[gamma], SREBP1
, and maturation markers such as leptin, FABP4, and adiponectin .
Also, the transcription factor motifs PAX5, EGR1, XBP1, SREBP1
, OLF1, MZF1, NFY, NFKAPPAB, MYCMAX, NFE2, and RP58 may contribute to the pathology of Down syndrome.
leucocephala fruit extract, expression levels of several genes, that is, protein kinases B (AKT), glucose transporter 4 (GLUT4), hormone sensitive lipase (HSL), phosphatidylinositol-3-kinases (PI3KA), and sterol regulatory element binding factor 1 (Srebp1
) (Table 1), were investigated.
miR-27a RXRa, ABCA1, FASN, RXRa, ABCA1, FASN, SREBP1
, SREBP2, SREBP1
, SREBP2, PPAR[alpha], PPAR[alpha], PPAR[gamma] ApoA1, PPAR[gamma] ApoA1, ApoB100, ApoE3 ApoB100, ApoE3 miR-27b PPAR[gamma], ANGPTL3, miR-27b is predicted to NDST1, GPAM target 27 mRNAs involved in lipid metabolism; targets in the second column have already been validated.
This multistep process is regulated at the transcriptional level by PPARs, SREBP1
, and PGC-1a and at the posttranscriptional level by ACC, malonyl-CoA decarboxylase (MCD), and carnitine O-palmitoyltransferase 1 (CPT1) regulation.
Hayek, "High glucose concentration increases macrophage cholesterol biosynthesis in diabetes through activation of the sterol regulatory element binding protein 1 (SREBP1
): inhibitory effect of insulin," Journal of Cardiovascular Pharmacology, vol.
For example, palmitoleic acid reduces hepatic steatosis by inhibiting the expression of sterol regulatory element binding protein-1 (SREBP1
), a transcription factor that is involved in the regulation of many enzymes involved in lipid synthesis .
Chung, "Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1
gene expression via AMPK-mTOR-p70S6K signaling pathway," Biological and Pharmaceutical Bulletin, vol.
Chen et al., "The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1
," Nature, vol.
Upregulation of CEBPB, CEBPG, SREBP1
and INSIG1 genes implied that ER stress-mediated lipid synthesis was activated.
The processing of SREBP1
and SREBP2 more than 60 min after the treatment with apoA-I is actually enhanced and the mature forms of these proteins were transported to the nuclei .