SREBF1

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SREBF1

A gene on chromosome 17p11.2 that encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor, which binds to the sterol regulatory element-1 (SRE1), a decamer flanking the low-density lipoprotein receptor gene and genes involved in sterol biosynthesis. The protein is synthesised as a precursor attached to the nuclear membrane and endoplasmic reticulum; once cleaved, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit precursor cleavage; the mature nuclear form is rapidly catabolised, reducing transcription.
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Estudio del factor de transcripcion SREBP1 en estados de resistencia a insulina.
XBP1 and SREBP1 motifs emphasized the participation of the activation of XBP1-ERAD pathway and lipid biogenesis potentially in CPT-induced ER stress.
We found that the livers of steers had higher lipid contents and lipogenic ACC mRNA levels, and mRNA levels of its regulator, SREBP1.
The expression of SREBP1 target genes ACACA, FASN, and SCD was suppressed by rapamycin, suggesting a role for mTORC1 in de novo synthesis of fatty acids (Soliman, 2011).