SREBF1

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SREBF1

A gene on chromosome 17p11.2 that encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor, which binds to the sterol regulatory element-1 (SRE1), a decamer flanking the low-density lipoprotein receptor gene and genes involved in sterol biosynthesis. The protein is synthesised as a precursor attached to the nuclear membrane and endoplasmic reticulum; once cleaved, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit precursor cleavage; the mature nuclear form is rapidly catabolised, reducing transcription.
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Statins downregulate the expression of crucial genes for adipocyte differentiation including C/EBPa, PPAR[gamma], SREBP1, and maturation markers such as leptin, FABP4, and adiponectin [103].
Also, the transcription factor motifs PAX5, EGR1, XBP1, SREBP1, OLF1, MZF1, NFY, NFKAPPAB, MYCMAX, NFE2, and RP58 may contribute to the pathology of Down syndrome.
leucocephala fruit extract, expression levels of several genes, that is, protein kinases B (AKT), glucose transporter 4 (GLUT4), hormone sensitive lipase (HSL), phosphatidylinositol-3-kinases (PI3KA), and sterol regulatory element binding factor 1 (Srebp1) (Table 1), were investigated.
miR-27a RXRa, ABCA1, FASN, RXRa, ABCA1, FASN, SREBP1, SREBP2, SREBP1, SREBP2, PPAR[alpha], PPAR[alpha], PPAR[gamma] ApoA1, PPAR[gamma] ApoA1, ApoB100, ApoE3 ApoB100, ApoE3 miR-27b PPAR[gamma], ANGPTL3, miR-27b is predicted to NDST1, GPAM target 27 mRNAs involved in lipid metabolism; targets in the second column have already been validated.
This multistep process is regulated at the transcriptional level by PPARs, SREBP1, and PGC-1a and at the posttranscriptional level by ACC, malonyl-CoA decarboxylase (MCD), and carnitine O-palmitoyltransferase 1 (CPT1) regulation.
Hayek, "High glucose concentration increases macrophage cholesterol biosynthesis in diabetes through activation of the sterol regulatory element binding protein 1 (SREBP1): inhibitory effect of insulin," Journal of Cardiovascular Pharmacology, vol.
For example, palmitoleic acid reduces hepatic steatosis by inhibiting the expression of sterol regulatory element binding protein-1 (SREBP1), a transcription factor that is involved in the regulation of many enzymes involved in lipid synthesis [24].
Chung, "Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1 gene expression via AMPK-mTOR-p70S6K signaling pathway," Biological and Pharmaceutical Bulletin, vol.
Chen et al., "The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1," Nature, vol.
Upregulation of CEBPB, CEBPG, SREBP1 and INSIG1 genes implied that ER stress-mediated lipid synthesis was activated.
The processing of SREBP1 and SREBP2 more than 60 min after the treatment with apoA-I is actually enhanced and the mature forms of these proteins were transported to the nuclei [31].