SREBF2

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SREBF2

A gene on chromosome 22q13 that encodes a ubiquitously expressed transcription factor with a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain, which controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The cognate gene product is required for lipid homeostasis: it regulates transcription of the LDL receptor gene, cholesterol and the fatty acid synthesis pathway.
References in periodicals archive ?
Garcia-Ruiz, "Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH," Journal of Hepatology, vol.
Dong, "Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6," Journal of Lipid Research, vol.
After that, the membranes were incubated with primary antibodies (SREBP-1 at 1:100 dilution; SREBP-2 at 1:200 dilution; ERa at 1:500 dilution and GAPDH at 1:10,000 dilution) at 4[degrees]C for 16 h.
Rapamycin down-regulates LDL-receptor expression independently of SREBP-2.
Scientists found decreased expression for almost all of the genes of cholesterol synthesis, including a gene called SREBP-2, which acts as a master regulator for cholesterol production.
Activation of PPAR[alpha] lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2, Biochem.
There were no significant difference in SREBP-2, ME, ICDH, ApoB and FABP2 mRNA expression between Kp-10 treated and control cells (p>0.
PCSK9 expression is downregulated by cholesterol via SREBP-2 (24) and upregulated by statins via SREBP-2 (25).
The study examined SREBP-2, an important gene in the body, and zeroed in on the microRNA miR-33, which is expressed within SREBP-2.
While SREBP-1a and SREBP-1c control the fatty acid pathways, SREBP-2 regulates the cholesterol biosynthetic pathway.
Several other groups have found a modest correlation between untreated PCSK9 and LDL-C concentrations (5, 6,9,10) that likely reflects coordinated upregulation of the LDLR and PCSK9 by SREBP-2 in response to higher cholesterol concentrations.