SREBF2

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SREBF2

A gene on chromosome 22q13 that encodes a ubiquitously expressed transcription factor with a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain, which controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The cognate gene product is required for lipid homeostasis: it regulates transcription of the LDL receptor gene, cholesterol and the fatty acid synthesis pathway.
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References in periodicals archive ?
Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins.
An increase of ER cholesterol above ~5 mol% results in the appearance of PFO-accessible cholesterol and in the disappearance of SREBP-2 in the nucleus controlled by SREBP cleavage-activating protein (SCAP).
Brown, "Akt acutely activates the cholesterogenic transcription factor SREBP-2," Biochimica et Biophysica Acta (BBA)--Molecular Cell Research, vol.
Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element- Binding Protein-2 (SREBP-2).
In cholesterol metabolism, AMPK activation by AICAR inhibited the expression of SREBP-2 and its target genes, HMGCR and 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS), which are key enzymes in cholesterol biosynthesis [45].
Garcia-Ruiz, "Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH," Journal of Hepatology, vol.
We found that the expression of SREBP-2, LXR and LDL-R genes all increased with the combined treatment of CA and FA.
Colell, "APP/PS1 mice overexpressing SREBP-2 exhibit combined A[beta] accumulation and tau pathology underlying Alzheimer's disease," Human Molecular Genetics, vol.
As previously discussed, PCSK9 mRNA is under the transcriptional regulation of SREBP-2; like the LDLR gene, PCSK9 is also regulated by intracellular sterol depletion and inhibitors of HMG CoA R inhibitors (statins)-type medications (53).
Two members of the miR-33 family-miR-33a and miR-33b-which differ in only two nucleotides and which are embedded in the introns of SREBP-2 and SREBP-1, respectively, are present in humans [57].
From the previous study, the miR96/182/183 cluster is regulated by SREBP-2 which is a function as it activates the expression of many key genes for cholesterol level and uptake.
After that, the membranes were incubated with primary antibodies (SREBP-1 at 1:100 dilution; SREBP-2 at 1:200 dilution; ERa at 1:500 dilution and GAPDH at 1:10,000 dilution) at 4[degrees]C for 16 h.