SREBF1

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SREBF1

A gene on chromosome 17p11.2 that encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor, which binds to the sterol regulatory element-1 (SRE1), a decamer flanking the low-density lipoprotein receptor gene and genes involved in sterol biosynthesis. The protein is synthesised as a precursor attached to the nuclear membrane and endoplasmic reticulum; once cleaved, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit precursor cleavage; the mature nuclear form is rapidly catabolised, reducing transcription.
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Based on our qPCR results, the expression levels of AdipoR2, ACC, FASN, and SREBP-1 were significantly up-regulated, suggesting that adiponectin interacts with AdipoR2 to regulate expression of ACC, FASN, and SREBP-1 genes in SMSCs.
Con: control group; SHP-1: small heterodimer partner 1; SREBP-1: sterol regulatory element binding protein-1; PPAR[alpha]: peroxisome-proliferator-activated receptor [alpha]; CYP7A1: cholesterol 7[alpha]-hydroxylase gene (CYP7A1); PEPCK: phosphoenolpyruvate carboxykinase; G6Pase: glucose-6-phosphatase.
Drug Class Effect on Proposed Mechanism of effect Author Acrp30 d4T NRTI [down arrow] Drug-induced mitochondrial [16] dysfunction in adipocytes EVG InSTI [down arrow] Alters adipocyte [79] differenciation and function RPV RPV [down arrow] Represses adipocyte [81] differentiation causing impaired expression of main adipogenesis regulators including; PPAR-[gamma], SREBP-1 and C/EBP-[alpha].
Second-hand smoke: stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1. J Hepatol.
(32) SREBP-1 regulates the growth and synthesis of glucose, differentiation and maturation of adipocytes and increased glucose through the adipocytes.
Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients.
HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein (ChREBP) activation.
Steatosis, steatohepatitis and fibrosis were common in HIV-patients with insulin resistance and steatosis was associated with an overexpression of SREBP-1 and a downregulation of PPAR[gamma]1 and PPAR[gamma]2; the latter were also inversely related to fibrosis.
The mechanism involved in lipodystrophy is related to the inhibition of the sterol regulatory enhancer-binding protein 1 (SREBP-1)-mediated activation of the heterodimer consisting of adipocytes retinoid x receptor and peroxisome proliferator-activated receptor [gamma](PPAR [gamma]) or related transcription factors such as PPAR [gamma] coactivator 1(7).