Based on our qPCR results, the expression levels of AdipoR2, ACC, FASN, and SREBP-1
were significantly up-regulated, suggesting that adiponectin interacts with AdipoR2 to regulate expression of ACC, FASN, and SREBP-1
genes in SMSCs.
Con: control group; SHP-1: small heterodimer partner 1; SREBP-1
: sterol regulatory element binding protein-1; PPAR[alpha]: peroxisome-proliferator-activated receptor [alpha]; CYP7A1: cholesterol 7[alpha]-hydroxylase gene (CYP7A1); PEPCK: phosphoenolpyruvate carboxykinase; G6Pase: glucose-6-phosphatase.
Drug Class Effect on Proposed Mechanism of effect Author Acrp30 d4T NRTI [down arrow] Drug-induced mitochondrial  dysfunction in adipocytes EVG InSTI [down arrow] Alters adipocyte  differenciation and function RPV RPV [down arrow] Represses adipocyte  differentiation causing impaired expression of main adipogenesis regulators including; PPAR-[gamma], SREBP-1
Second-hand smoke: stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1
. J Hepatol.
regulates the growth and synthesis of glucose, differentiation and maturation of adipocytes and increased glucose through the adipocytes.
Altered hepatic expression of SREBP-1
and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients.
HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1
and carbohydrate-response element-binding protein (ChREBP) activation.
Steatosis, steatohepatitis and fibrosis were common in HIV-patients with insulin resistance and steatosis was associated with an overexpression of SREBP-1
and a downregulation of PPAR[gamma]1 and PPAR[gamma]2; the latter were also inversely related to fibrosis.
The mechanism involved in lipodystrophy is related to the inhibition of the sterol regulatory enhancer-binding protein 1 (SREBP-1
)-mediated activation of the heterodimer consisting of adipocytes retinoid x receptor and peroxisome proliferator-activated receptor [gamma](PPAR [gamma]) or related transcription factors such as PPAR [gamma] coactivator 1(7).