SREBF1

SREBF1

A gene on chromosome 17p11.2 that encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor, which binds to the sterol regulatory element-1 (SRE1), a decamer flanking the low-density lipoprotein receptor gene and genes involved in sterol biosynthesis. The protein is synthesised as a precursor attached to the nuclear membrane and endoplasmic reticulum; once cleaved, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit precursor cleavage; the mature nuclear form is rapidly catabolised, reducing transcription.
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MIDT) increased the expression of PPARG, CEBPA, FABP4, LPL, PLIN, and SREBF1 throughout the differentiation process as illustrated in Figure S2.
DNA polymorphisms in SREBF1 and FASN genes affect fatty acid composition in Korean cattle (Hanwoo).
This treatment significantly inhibited the expression of SCD1 and SREBF1, which mediate lipogenesis, and tended to decrease expression of ACACA (Fig.
The SREBF2 gene is in the same family as SREBF1, linked to type 2 diabetes in another CardioChip study.
Steroid receptor element--binding protein 1c (SREBP-1c or SREBF1, also referred to as "adipocyte determination and differentiation factor 1," or "ADD-1") is an important candidate gene for metabolic adverse events associated with HIV infection and treatment.
3] Human genes: SCD, stearoyl-CoA desaturase (delta-9-desaturase); ACACA, acetyl-Coenzyme A carboxylase alpha; FASN, fatty acid synthase; SREBF1, sterol regulatory element binding transcription factor 1.
Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression.
CCAAT/enhancer-binding protein alpha (C/EBP[alpha]) and SREBF1 (Ahn et al.
5] Human genes: FASN, fatty acid synthase; ACACA, acetyl-Coenzyme A carboxylase alpha; SREBF1, sterol regulatory element binding transcription factor 1 SCD, stearoyl-CoA desaturase (delta-9-desaturase).
CXCL12, C5 Tachycardia Imipramine GRIN2B, ADORA3, KCNH7, CHRNA7, KCNG2, KCNQ1, CHRNA5, ADORA1, CASQ2, ADRA1B, ADRB3, ADRA1D Kidney failure Imipramine EPO, ALB, EDNRA, FKBP1A, NR3C2, VDR, PPP3CA Glomerular injury EtOH-Fr SREBF1 Cardiac congestive Cardiac failure Imipramine EPO, NOS1.
Recent studies have reported associations between fatty acid composition of beef and polymorphisms in candidate genes like SREBF1 (Hoashi et al.
Our results showed that high expression of SCD and SREBF1 may be one of the reasons that larger fat deposits are observed in the XP.