NCOA3

(redirected from SRC3)
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NCOA3

A gene on chromosome 20q12 that encodes a nuclear receptor coactivator, which interacts with nuclear hormone receptors to enhance transcription. NCOA3 has histone acetyltransferase activity and recruits other proteins, forming a multi-unit coactivation complex. It first appears in the cytoplasm but is translocated into the nucleus upon phosphorylation.
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Cells were transfected with a 3xERE-luc reporter plasmid, pRL-TK plasmid, mER[beta]2 or mER[beta]1 expression plasmid, and expression plasmids for SRC1, SRC2, or SRC3.