NCOA3

(redirected from SRC3)
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NCOA3

A gene on chromosome 20q12 that encodes a nuclear receptor coactivator, which interacts with nuclear hormone receptors to enhance transcription. NCOA3 has histone acetyltransferase activity and recruits other proteins, forming a multi-unit coactivation complex. It first appears in the cytoplasm but is translocated into the nucleus upon phosphorylation.
References in periodicals archive ?
Furthermore, mER[beta]2 exhibited reduced co-activation in the presence of EDCs, only selectively recruiting SRC2 or SRC3. Given the increasing use of experimental animal models to study the effects of EDCs, mER[beta]2 and its aberrant role in estrogen signaling should be considered when investigating mechanisms of toxicity.
Cells were transfected with a 3xERE-luc reporter plasmid, pRL-TK plasmid, mER[beta]2 or mER[beta]1 expression plasmid, and expression plasmids for SRC1, SRC2, or SRC3. After 18 hr, transfected cells were treated with Ej at 10-7 M (for mER[beta]2) or [10.sup.-8] M (for mER[beta]1), or BPA, BPAF, HPTE, or Gen at [10.sup.-6] M.
Nevertheless, recruitments of other coactivators, namely, SRC1, SRC2, SRC3, and TRAP1b (MED1), were significantly inhibited by CDK5-mediated phosphorylation of the receptor.