NCOA1

(redirected from SRC1)
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NCOA1

A gene on chromosome 2p23 that encodes a protein of the p160/steroid receptor coactivator family, which acts as a transcriptional coactivator for steroid and nuclear hormone receptors, coactivating different nuclear receptors—e.g., PGR, GR and ER, retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors, and may participate in chromatin remodelling and recruitment of general transcription factors. NCOA1 acts with NCOA2 to control energy balance between white and brown adipose tissues.
References in periodicals archive ?
Cells were transfected with a 3xERE-luc reporter plasmid, pRL-TK plasmid, mER[beta]2 or mER[beta]1 expression plasmid, and expression plasmids for SRC1, SRC2, or SRC3.
Nevertheless, recruitments of other coactivators, namely, SRC1, SRC2, SRC3, and TRAP1b (MED1), were significantly inhibited by CDK5-mediated phosphorylation of the receptor.
Um, "Additional sex comb-like 1 (ASXL1), in cooperation with SRC1, acts as a ligand-dependent coactivator for retinoic acid receptor," Journal of Biological Chemistry, vol.
On binding to DNA, PPAR[gamma] recruits transcriptional coactivators such as steroid receptor coactivator 1 (SRC1) and positively regulates the expression of target genes [3, 4].
Both RIF and BPA strongly promoted the specific interaction of steroid receptor coactivator-1 (SRC1) and peroxisome proliferator-activated receptor-binding protein (PBP) in a dose- dependent manner (Figure IE).
In addition, this dimer can interact with other coactivators proteins like CBP/p300, SRC1, PBP, and PGC-1[alpha] to induce a specific gene expression (Figure 1) 3, 4].
Employment of the human estrogen receptor beta ligand-binding domain and co-activator SRC1 nuclear receptor-binding domain for the construction of a yeast two-hybrid detection system for endocrine disrupters.
Core LXXLL motif sequences in CBP, SRC1 and RIP140 define affinity and selectivity for steroid and retinoid receptors.