NCOA1

(redirected from SRC1)
Also found in: Acronyms.

NCOA1

A gene on chromosome 2p23 that encodes a protein of the p160/steroid receptor coactivator family, which acts as a transcriptional coactivator for steroid and nuclear hormone receptors, coactivating different nuclear receptors—e.g., PGR, GR and ER, retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors, and may participate in chromatin remodelling and recruitment of general transcription factors. NCOA1 acts with NCOA2 to control energy balance between white and brown adipose tissues.
References in periodicals archive ?
Cells were transfected with a 3xERE-luc reporter plasmid, pRL-TK plasmid, mER[beta]2 or mER[beta]1 expression plasmid, and expression plasmids for SRC1, SRC2, or SRC3.
1] Scans 128 and 500 for 40 kHz Source SRC1 Scan gain range radius 40 points Effective laser wavenumber (ELWN) 15800.
Employment of the human estrogen receptor beta ligand-binding domain and co-activator SRC1 nuclear receptor-binding domain for the construction of a yeast two-hybrid detection system for endocrine disrupters.