CXCL16

(redirected from SR-PSOX)

CXCL16

A gene on chromosome 17p13 that encodes a protein that acts as a scavenger receptor on macrophages, specifically binding to oxLDL (oxidised low-density lipoprotein), suggesting that it may play a role atherogenesis. CXCL16 induces a brisk chemotactic response and mobilises calcium.
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Buers, "SR-PSOX at sites predisposed to atherosclerotic lesion formation mediates monocyte-endothelial cell adhesion," Atherosclerosis, vol.
Minami et al., "Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages," The Journal of Biological Chemistry, vol.
As a transmembrane molecule, CXCL16 (also known as SR-PSOX) acts as a scavenger receptor for oxidized low-density lipoprotein (oxLDL) uptake, suggesting the involvement of CXCL16 in lipid metabolism [6].