selective progesterone receptor modulator

(redirected from SPRM)
Also found in: Acronyms, Wikipedia.

selective progesterone receptor modulator

,

SPRM

A class of medications that attach to cellular binding sites for the hormone progesterone, and either stimulate those sites, block them, or both block and stimulate them. They have a variety of uses in obstetrics and gynecology. Antagonist (blocking) agents like mifepristone can induce abortion. Agonist (receptor-stimulating) drugs may be used to treat uterine fibroids.
Mentioned in ?
References in periodicals archive ?
In the second stage, the processes related to KM were identified in each of the SPRM included in the review.
By following the steps of the methodology, the main results were: 1) the selection of five SPRM, 2) the identification of 19 processes related to the KM in the SPRM, and 3) the mapping of the 19 processes in relation to KM schools and the KM capabilities.
The selection of SPRM began with the definition of the search equations used in the ISI Web of Knowledge and SCOPUS databases.
The data extraction focused on classifying the articles according to the referenced SPRM in the content as part of the theoretical foundation or as methodological sustenance.
After the analysis, the first result was the selection of five SPRM: 1) the international standard, ISO/IEC 12207, 2) the Brazilian SPRM called MPS.
Identification of related processes with KM in the SPRM
The process analysis to identify those that contain aspects related to KM resulted in a set of 19 processes out of 101 processes from the five selected SPRM.
In relation to the analysis of the SPRM regarding the KM schools it was discovered that most of the identified aspects are related to the school system.
Otros SPRM como dex-mesilato, dex-oxetanona, J912, J956, J1042, LG 120920, ORG33628, ORG 31710 han sido menos estudiados, por lo cual existen pocas publicaciones.
El SPRM ideal debera tener el potencial para proveer efecto antiproliferativo en el endometrio y seno, efecto protector estrogenico en ovario, hueso y sistema cardiovascular; y efecto neutral sobre el sistema nervioso central.
Son multiples y prometedoras las aplicaciones clinicas de los SPRM.
No ha sido encontrado el SPRM ideal para uso combinado con progestinas que no comprometa la inhibicion de la ovulacion como resultado de la competitividad entre la progestina y el antiprogestageno por PR en el hipotalamo hipofisiario.