MAP3K11

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MAP3K11

An oncogene on chromosome 11q13.1-q13.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K11 activates the JUN N-terminal pathway; it is required for serum-stimulated cell proliferation and for mitogen and
cytokine activation of MAPK14/p38, MAPK3/ERK and MAPK8/JNK1, through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. MAP3K11 plays a role in mitogen-stimulated phosphorylation and activation of BRAF; it influences microtubule organisation during the cell cycle, and is expressed in a wide range of benign and malignant tissues.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
References in periodicals archive ?
There are plenty of Sphero games and activities available from SPRK and others.
The company also unveiled details of an expanded pilot program for its SPRK Travel Agency Platform.
Coding & Programming for All Ages- Children of all ages will get to experience programming firsthand with Spheros SPRK, a robot simple enough for beginners, yet sophisticated enough for seasoned programmers; Ozobot and Dash Robot will give children ages six through eight an up-close look at how learning to code can lead to custom programming; and Fisher-Prices Code-a-pillar will introduce children as young as three-years-old to the fundamental constructs of coding.