MAP3K11

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MAP3K11

An oncogene on chromosome 11q13.1-q13.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K11 activates the JUN N-terminal pathway; it is required for serum-stimulated cell proliferation and for mitogen and
cytokine activation of MAPK14/p38, MAPK3/ERK and MAPK8/JNK1, through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. MAP3K11 plays a role in mitogen-stimulated phosphorylation and activation of BRAF; it influences microtubule organisation during the cell cycle, and is expressed in a wide range of benign and malignant tissues.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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References in periodicals archive ?
There are plenty of Sphero games and activities available from SPRK and others.
The Commission is also concerned to see that the "SPRK's proposal could also make it possible for mobile operators to refuse or delay access to their networks in an attempt to eliminate their direct competitors".