SPI1


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SPI1

A gene on chromosome 11p11.2 that encodes a transcription protein that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') which can act as a lymphoid-specific enhancer. SPI1 may be involved in the differentiation or activation of macrophages or B-cells; it binds RNA and may modulate pre-mRNA splicing.
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We observed lower mean (SD) gene expression at P2 vs R2 for all genes: GATA1 70 (12)%, RUNX1 50 (11)%, NCAM1 41 (8)%, and SPI1 51 (6)%.
The genes to be analyzed were selected because of their attributes as key regulators during different stages of hematopoiesis and leukemogenesis, as well as their more or less distinct organ specificity: NCAM1 and RUNX1 as representatives of genes with functions (hematopoiesis, osteogenesis, cell adhesion) on many cell types (hematopoietic cells, neurons, muscles) of various differentiated tissues (embryonic cells, differentiated cells), GATA1 and SPI1 having more circumscribed compartments and cell types (erythropoiesis/megakaryopoiesis, myelopoiesis, and lymphopoiesis).
4] Human genes: RUNX1, runt-related transcription factor 1; GATA1, GATA binding protein 1; SPI1, spleen focus forming virus proviral integration oncogene 1; NCAM1, neural cell adhesion molecule 1.