ATP2C2

(redirected from SPCA2)

ATP2C2

A gene on chromosome 16q24.1 that encodes a magnesium-dependent enzyme that catalyses the hydrolysis of ATP coupled with calcium transport.
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References in periodicals archive ?
The Hopkins study focused on the enigmatic molecular machines known as SPCA2 that are found in very high levels in human breast cancer cells.
Historically, SPCA2 were assumed to be redundant and less essential versions of better-known calcium pumps that scavenge calcium inside of cells everywhere in the body and store it away.
Mingye Feng, a graduate student of physiology in the Johns Hopkins University School of Medicine, learned that wasn't necessarily the case as he conducted a standard control experiment and put the gene that codes for the SPCA2 pump into an ordinary human cell.
Sequence polymorphism in the direct repeat region of the chromosome and IS 1548 profiling data support the hypothesis that M1 organisms have two main evolutionary lineages marked by the presence or absence of the spcA2 allele encoding streptococcal pyrogenic exotoxin A2.