PCSK1

(redirected from SPC3)

PCSK1

A gene on chromosome 5q15-q21 that encodes a peptidase S8 family convertase involved in processing pairs of basic amino acid residues located on prohormones and other protein precursors (e.g., POMC, renin, enkephalin, dynorphin, somatostatin and insulin).

Molecular pathology
Defects in PCSK1 cause proprotein convertase 1 deficiency.
References in periodicals archive ?
Each inch-wide module contains a 16-bit A/D converter, a microcontroller for intelligent signal processing, and an SPC3 ASIC to communicate with the Profibus network.
In this group, SPC3 had the closest relations with the decrease in cost of quality, growth of productivity and increase of profit, which determined our decision to include this variable in the regression equations and to exclude the rest of the variables in the group.
In laboratory tests, SPC3 blocks the spread of infection by many different strains of HIV, including those resistant to AZT.
We are encouraged by the recent developments in HIV co-receptor research, but must caution everyone that SPC3 is still in a very early stage of development," said William J.
clinical trials for their AIDS therapy drug, SPC3 (Synthetic Polymeric Construction No.
The primary objective of the clinical trials (Phase I/II studies) which begin this fall, is to determine the optimal dosage of SPC3 in late stage seropositive patients.
SPC3 protects the human cells including CD4+ lymphocytes, macrophages and CD4- negative cells by obstructing entry of the HIV virus.
In-vitro studies have demonstrated that SPC3 effectively blocks entrance of all strains of the virus into human cells, unlike previously tested antiviral agents and vaccines that are strain specific.
ASE:COB) Thursday announced that it commenced Phase II/III clinical trials in the United Kingdom for SPC3, a potential AIDS treatment.
The objective of the studies is to demonstrate that SPC3 inhibits production of the AIDS virus and prevents progression to full blown AIDS in patients with late stage HIV infection.
We are excited with the progress on the development of SPC3,'' said William J.
A synthetic multi-branched peptide, SPC3 contains eight repeats of the consensus region of the V3 loop of the HIV-1 (AIDS) virus surface envelope glycoprotein gp120.