FURIN

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FURIN

A gene on chromosome 15q26.1 that encodes a ubiquitous endoprotease, located in the trans-Golgi network membrane of the Golgi apparatus, which is involved in constitutive secretory pathways, cleaving proproteins at the RX(K/R)R consensus motif. Furin releases albumin, complement C3 and vWF from their respective precursors.

Furin has an inhibition peptide, which serves as an intramolecular chaperone, that is autocatalytically removed in the endoplasmic reticulum and remains non-covalently bound to furin as a potent autoinhibitor. After transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
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References in periodicals archive ?
Russell, "Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast," Genes and Development, vol.
While news of the attacks hit after markets closed on Friday, S&P 500 Index futures SPc1 were still trading and shed about 1 percent in light volume.
The materials of the socket, bearing, plug, and ball stud are SM45C, nylon, SPC1, and SCM435 [1-3], respectively.
Financial bookmakers expected Europes main indexes, which finished the last session in positive territory, to open up 0.4-0.8 percent, but S&P 500 futures SPc1 fell 0.4 percent, suggesting at least a pause in Wall Streets sharp rally.
Shares of Goldman rose 8.1 percent after the announcement, while Standard & Poor s 500 futures SPc1 gained 15 points.
For example, since there were 100 new points to allocate, and SPCI accounts for 64% of the variance, 64 points were assigned to SPC1. In each case, points were selected randomly within the each stratum to ensure independence of sample measurements (Brus and De Gruijter 1997).
The first component (SPC1) had approximately equal contributions from DEM, LST, and CTI.
Also, when compared in the feature space using SPC1 and SPC2 as axes, ER and free survey (ORIG) showed a higher spread towards the centre of the feature space cloud (Fig.