SPAG5

SPAG5

A gene on chromosome 17q11.2 that encodes sperm-associated antigen 5, which is an essential component of the mitotic spindle and required for normal chromosome segregation and progression to anaphase. SPAG5 is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture.
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Through our GO network analysis, 17 of 73 genes, i.e., ATP binding cassette subfamily A member 13 (ABCA13), actin alpha2 (ACTN2), ATPase phospholipid transporting 9A (ATP9A), C2 calcium dependent domain containing 3 (C2CD3), centrosomal protein 152 (CEP152), growth hormone (GH), glucagon like peptide 2 receptor (GLP2R), GNAS complex locus (GNAS), interleukin 22 receptor subunit alpha 2 (IL22RA2), microtubule associated protein 1 light chain 3 beta (MAP1LC3B), I-BAR domain containing (MTSS1), olfactomedin 1 (OLFM1), slowmo homolog 2 (SLMO2), prominin 1 (PROM1), sperm associated antigen 5 (SPAG5), transforming growth factor beta receptor 3 (TGFBR3), ubiquitin specific peptidase 36 (USP36), were found associated with six major GO terms.
Three genes (C2CD3, CEP152, SPAG5) were associated with protein localization to the centrosome, cytoskeleton, and microtubule cytoskeleton (Figure 3).
In this study, C2CD3, along with CEP152 and SPAG5, was associated with protein localization to the centrosome, cytoskeleton, and microtubule cytoskeleton in the GO network analysis.
Like C2CD3, CEP152, and SPAG5 each had ranking p-values of <0.05 but there is only one SNP thought to cause a significant amino-acid substitution (Table 2).
Furthermore, all three genes (C2CD3, CEP152, SPAG5) associated with protein localization to the centrosome in our GO ontology were included among this 13-gene set, and contained more nsSNPs than others in the Berkshire selective-sweep region.
The interaction of SPAG5 and TOP2A had the second higher weight value of 0.999832.