SOX6

SOX6

A gene on chromosome 11p15.3 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate normal development of the CNS, chondrogenesis and maintenance of cardiac and skeletal muscle cells.
Mentioned in ?
References in periodicals archive ?
Expression levels of miR-208, associated with cardiac hypertrophy by negative regulation of SOX6, were also found significantly increased in the peripheral blood of patients with left ventricular hypertrophy compared with those of healthy individuals, suggesting that it may be useful as a novel therapeutic and diagnostic marker for cardiac hypertrophy (8).
Furthermore, miR-499 protects cardiomyocytes from oxidative stress induced apoptosis via its effects on Pdcd4, Pacs2, and SOX6 [92, 93].