Sex-determining region Y-box 4 (Sox4
) is a member of the sex-determining region Y (SRY)-related high-mobilitygroup (HMG-box) family (15).
Moreover, it is also demonstrated that the antiapoptosis gene AVEN and the transcription factor-related genes FOXD1, TFDP1, IDH1, SEC23A, SOX4
, Runx2 , DTL, ATF3, MYC , HIF2a , and SEPT7  are all involved in nonattachment growth via miR-30a  (Figure 1).
found that SOX4
in synovium-derived MSCs (SMSCs) can promote SMSC proliferation and differentiate into chondrocytes by upregulating lncRNA DANCR.
Bcl2, Ccnd1, Cdk6, and Sox4
), intestinal stem cells (Lgr5, Olfm4, and Bmi1) , mucin biology (Muc2 and Muc6), and tight junctions (occludin, zonulin-1, and Jam) was analyzed using real-time PCR (Table S1).
 reported that lncRNA-UCA1 as a competing endogenous RNA (ceRNA) of Sox4
enhanced tumor cell proliferation by targeting miR-204 and Sox4
and Bian et al.
Upregulated expression of SOX4
is associated with tumor growth and metastasis in nasopharyngeal carcinoma.
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4
, and IRX3.
Wang et al., "Metformin inhibits epithelial-mesenchymal transition in prostate cancer cells: involvement of the tumor suppressor miR30a and its target gene SOX4
," Biochemical & Biophysical Research Communications, vol.
miR-204, methylated and downregulated in glioma, when activated suppresses the expression of stem transcription factor SOX4
, reduces cell invasion, and prolongs survival in animal models .
In TGF-[beta]-sensitive PDAC cells, EMT becomes lethal by changing TGF-[beta]-induced Sox4
from a tumorigenic inducer to an apoptosis promoter, evidence that supports the uncoupling of EMT and stemness, especially in PDAC.
Estrogen induces androgen-repressed SOX4
expression to promote progression of prostate cancer cells.
and metastasis###let-7 (LIN28, HMGA2), miR-30a(vimentin), miR-7 (Pak 1), miR-126(SOX4
, TNC), miR-10b