In a study investigating the conditions that influence the response to Fgf during otic placode induction (13), signaling of this factor has been shown to induce the expression of zebrafish otic genes such as pax8, pax2a, fgf24, and sox3
throughout the preplacodal region, which is important in setting the pattern of the otic vesicle.
Expression of Nestin, Transcription Factor SOX3
and Homeobox Protein DLX-4 in the Facial Tissue of Children with Cleft Lip and Palate
Previous studies have reported that several members of the Sox gene family, including Sox2, Sox3
and Sox14 participate in neurogenesis (Gao et al., 2015; Djurovic and Stevanovic, 2004; Dvorakova et al., 2016).
122 - SOX2 AND SOX3
EXPRESSION IN TWO COLORECTAL CELL LINES: HCT-116 AND HT-29.
The results also indicated SOX2OT might act as ceRNAs to maintain the expression of SOX3
by buffering miR-122 and miR-194-5p.
A recent study demonstrated that Sox2, a member of the SoxB1 group along with Sox1 and Sox3
, is required for the development of sensory epithelia, including the organ of Corti [14-17].
During iPSC reprogramming via expression of Oct4, Sox3
, Klf4, and cMyc, exogenous Oct4 binds to both MyoD enhancers which may lead to the bivalent state characteristic of pluripotent stem cells.
Several transcription factors have been identified that can promotes permatogonial differentiation (DMRT1, NGN3, SOHLH1, SOHLH2, SOX3
, and STAT3), some of which may affect the fate of SSCs either to differentiate or to promote later spermatogonial differentiation steps.
Guo, "Over-expression of Sox3
is associated with diminished prognosis in esophageal squamous cell carcinoma," Annals of Surgical Oncology, vol.
Other sex-determining genes include gsdf, sox3
, and sdY in Oryzias luzonensis, Oryzias dancena, and Oncorhynchus mykiss, respectively [9-11].
Pax6 influences target gene expression both independently and in association with other transcription factors such as pRb, MafA, MitF, Sox2, AP2[alpha], and Sox3
. Sox2 and Sox3
interact with Pax6, leading to synergistic transcriptional activation .
Mutations in the genes HESX1, SOX2, SOX3
and OTX2 have been implicated.