SOX2


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SOX2

A gene on chromosome 3q26.3-q27 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX2 is required for stem-cell maintenance in the CNS and regulates gene expression in the stomach.

Molecular pathology
SOX2 mutations are associated with optic nerve hypoplasia and syndromic microphthalmia.
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References in periodicals archive ?
Undifferentiated embryonic stem cell (ESC) identity is maintained by transcription factors (TFs) of the pluripotency gene regulatory network (PGRN) centred on the TFs Oct4, Sox2 and Nanog.
CACOHET: Causes and consequences of pluripotency gene regulatory network member heterogeneity
What the researchers found is that the transcription factor of a DNA binding protein called sex determining region Y box 2, or Sox2 for short, which normally maintains cell self-renewal, actually releases the floodgates in the Hippo pathway in osteosarcomas and other cancers, permitting the growth of highly aggressive, tumor-forming stem cells.
Key Mechanism Identified In Pediatric Bone Cancers That Allows Proliferation Of Tumor-Forming Stem Cells
In recent years, reprogramming genes such as Oct3/4, Sox2, Klf4 and cMyc have been widely studied for tissue regeneration.
Scopoletin has a potential activity for anti-aging via autophagy in human lung fibroblasts
At the fourth day after hypoxic precondition treatments cells were analysed for the expression of surface marker CD90 and CD34 by flowcytometry, and for transcription factors OCT4 and SOX2 by immunocytochemistry and immunofluorescence microscopy.
Hypoxic preconditioning for viable and self renewing mesenchymal stem cells (Mscs) as the regeneration of spermatogenesis process
After conducting a series of studies, the researchers reported that cells localized at the base of the hair follicle (dermalpapilla) expressed the stem cell marker Sox2 and exhibited the property to grow in colonies in the form of spheres, both characteristics of dermal stem cells.
Support healthy hair and scalp regeneration
The second group included regulators of pluripotency pathways that were predicted to be activated, such as SOX2 (SRY-box containing gene 2), NANOG, KLF4 (Kruppellike factor 4), and OCT4.
Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis
Even more intriguingly, they highlight that RMST controls SOX2 by directly interacting with the protein.
Scientists at Genome Institute of Singapore Discover Gene that Controls the Birth of Neurons
Yamanaka reported that adult mouse fibroblasts could be induced to form pluripotent cells by expressing just four genes (Oct4, Sox2, Klf4, and c-Myc).
Shinya Yamanaka, M.D., Ph.D.--2012 Nobel Prize Laureate: how his dream of a research career provides vision for the next generation of young scientists/2012 Nobel Odul Laureat'i Dr. Shinya Yamanaka'nin arastirma kariyeri dusleri gelecek nesil genc bilim adamlarina nasil bir vizyon aktariyor
Bass et al (78) showed that SOX2 is an amplified lineage-survival oncogene in lung squamous cell carcinoma.
Molecular profiling in non-small cell lung cancer: a step toward personalized medicine
multipotency) and maintains the cells' stem-cell-like characteristics by directly controlling the regulatory molecules OCT4 and SOX2 (Yu et al.
Epigenetic events in liver cancer resulting from alcoholic liver disease
This was achieved in ground-breaking studies in 2006/7 by Takahashi and Yamanaka, who showed that the ectopic expression of four key embryonic regulatory genes (Oct3/4, Sox2, Klf4 and c-Myc) reactivates endogenous pluripotency genes in mouse and human fibroblasts.
A new class of stem cells in South Africa: iPS cells
SOX2 anophthalmia syndrome: 12 new cases demonstrating broader phenotype and high frequency of large gene deletions.
Detection of partial deletions of Y-chromosome AZFc in infertile men using the multiplex ligation-dependent Probe Amplification assay

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