SOX2


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SOX2

A gene on chromosome 3q26.3-q27 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX2 is required for stem-cell maintenance in the CNS and regulates gene expression in the stomach.

Molecular pathology
SOX2 mutations are associated with optic nerve hypoplasia and syndromic microphthalmia.
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References in periodicals archive ?
The research team targeted two genes that are only expressed in stem cells and known to be integral to pluripotency: Sox2 and Oct4.
CRISPR Genome Activation Transforms Skin Cells Into Stem Cells
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.
Alternative Splicing Generates Different 5' UTRs in OCT4B Variants
2012) Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells.
Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders
SOX2 promotes the epithelial to mesenchymal transition of esophageal squamous cells by modulating slug expression through the activation of STAT3/HIF-a signaling.
Transforming Growth Factor-beta 1 Involved in the Pathogenesis of Endometriosis through Regulating Expression of Vascular Endothelial Growth Factor under Hypoxia
The results showed that 500 ng/mL ascorbic acid treatment in the first 24 h of embryo development significantly increased the expression levels of Pou5f1, Sox2, and Klf in blastocysts (Figure 3).
Ascorbic acid increases demethylation in somatic cell nuclear transfer embryos of the pig (Sus scrofa)
As shown in Figure 3, Creb314, Tpd52, Pitx3, Paqr4, and Sox2 were hypomethylated at promoter CpG sites by neonatal high-dose [E.
Prostate cancer risk and DNA methylation signatures in aging rats following developmental BPA exposure: a dose-response analysis
SOX1, SOX2 and NES expression was also reduced dramatically with differentiation, showing very small positive populations at 8 weeks (2%, 3% and 2%, respectively) (Fig.
A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity
Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells.
Induced pluripotent stem cells: inventors turning into competitors tagline: can a competitive patent combat yield better inventions in stem cell research?
Furthermore, we showed that CA promoted proteasomal degradation of several substrate proteins, including Cyclin Bl, retinoblastoma (RB), SOX2, and glial fibrillary acid protein (GFAP), whereas MYC levels were not modified.
Carnosic acid induces proteasomal degradation of Cyclin B1, RB and SOX2 along with cell growth arrest and apoptosis in GBM cells
pylori] inhibits the expression of SOX2 in gastric epithelial cells, hence activating transcription factor CDX2 as a counterpart to MUC5AC gene inhibition andMUC2 gene induction," elaborated Dr.
A Bug's Story: H. Pylori and Stomach Cancer - PiscoMed's Journal AMOR Releases a Study on Intestinal Metaplasia
The research findings described in this media release can be found in the Cell Journal, under the title, "Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo" by Melanie D.
Real-Time Imaging of Embryo Development Could Pave the Way for More Effective Human Reproduction Therapies
Sheep gene mapping: Assignment of ALDOB, CYP19, WT and SOX2 by somatic cell hybrid analysis.
Polymorphism C242T in the Cyp19 gene in meat sheep/Polimorfismo no gene cyp19 em ovinos de corte

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