Representative ER pathway genes including ESR1, BMP4, DKK1, SOX11
, SNCG, and MOSC1 are downregulated by promoter methylation, which are in accordance with decreased expression of ER-[alpha].
Immunoperoxidase stains revealed that the expanded mantle zone cells (neoplastic B cells) were positive for CD20 (Figure 4), CD5 (Figure 5), CD43 (Figure 6), cyclin D1 (Figure 7), and SOX11
Lei, "Transcription factor Sox11
is essential for both embryonic and adult neurogenesis," Developmental Dynamics, vol.
A comparative analysis of human neuroblastoma cells and the neuroblastoma obtained from primary cultures of mouse neural crest cells demonstrated that, in addition to the upregulation of genes associated with the passage through the cell cycle, both neuroblastomas upregulate the transcription factors characteristic of embryonic development of the nervous system, including those important for neural crest development, that is, Sox11
, Nhlh2, Twist1, Ascl1, Insm2, and Tcf3 .
It must be distinguished from other small B-cell lymphomas based on negative staining for CD10, BCL6, CD5, cyclin D1, and SOX11
CD5 was positive; Cyclin D1 and SOX11
were negative, which also excludes mantle cell lymphoma.
To confirm the transcriptional activity of the binding sites found for the Sox trio near some of these targets, luciferase assay was carried out for the Sox trio-bound enhancers of Fbxl18, Rad51c, Sox11
, Sox5, Sox6, Tgfb2, and Tle3.
Cardiac outflow tract development relies on the complex function of Sox4 and Sox11
in multiple cell types.
Strong lymphoid nuclear expression of SOX11
transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.
When researchers analyzed morphine-induced changes in gene expression in the nucleus accumbens, the area of the brain in which morphine caused no reward or response they found that two genes, sox11
and gadd45g, mediated the brain's response to morphine, preventing any reward and addiction.
Embryonic expression of the chicken Sox2, Sox3 and Sox11
suggests an interactive role in neuronal development.