SOX11

SOX11

A gene on chromosome 2p25 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX11 may act as a transcription regulator after forming a complex with other proteins; it may play a role in development of the nervous system and in tumourigenesis.
References in periodicals archive ?
Representative ER pathway genes including ESR1, BMP4, DKK1, SOX11, SNCG, and MOSC1 are downregulated by promoter methylation, which are in accordance with decreased expression of ER-[alpha].
Immunoperoxidase stains revealed that the expanded mantle zone cells (neoplastic B cells) were positive for CD20 (Figure 4), CD5 (Figure 5), CD43 (Figure 6), cyclin D1 (Figure 7), and SOX11 (Figure 8).
Lei, "Transcription factor Sox11 is essential for both embryonic and adult neurogenesis," Developmental Dynamics, vol.
A comparative analysis of human neuroblastoma cells and the neuroblastoma obtained from primary cultures of mouse neural crest cells demonstrated that, in addition to the upregulation of genes associated with the passage through the cell cycle, both neuroblastomas upregulate the transcription factors characteristic of embryonic development of the nervous system, including those important for neural crest development, that is, Sox11, Nhlh2, Twist1, Ascl1, Insm2, and Tcf3 [53].
It must be distinguished from other small B-cell lymphomas based on negative staining for CD10, BCL6, CD5, cyclin D1, and SOX11 (see below).
CD5 was positive; Cyclin D1 and SOX11 were negative, which also excludes mantle cell lymphoma.
To confirm the transcriptional activity of the binding sites found for the Sox trio near some of these targets, luciferase assay was carried out for the Sox trio-bound enhancers of Fbxl18, Rad51c, Sox11, Sox5, Sox6, Tgfb2, and Tle3.
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.
When researchers analyzed morphine-induced changes in gene expression in the nucleus accumbens, the area of the brain in which morphine caused no reward or response they found that two genes, sox11 and gadd45g, mediated the brain's response to morphine, preventing any reward and addiction.
Embryonic expression of the chicken Sox2, Sox3 and Sox11 suggests an interactive role in neuronal development.