SOST


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SOST

A gene on chromosome17q11.2 that encodes sclerostin, a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

Molecular pathology
Loss-of-function mutations in SOST are linked to sclerosteosis; a deletion downstream of SOST causes reduced sclerostin expression, resulting in a milder sclerosteosis (van Buchem disease).
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In recent years, SOST has learned the critical strategic impact they have for local fighters.
SR decreased the levels of SOST and RANKL, but there was no significant difference between the KO control group and the KO SR group.
are all planning to go on an indefinite strike in Sost on 15 May 2018.
Finally, a study in a CKD mouse model reported that knocking out the SOST gene did not substantially affect bone structure, the only reported effect was being a decreased number of osteoclasts in the vertebrae, which could potentially be explained by a stimulation of RANKL by sclerostin [119].
Sost is the last border town on KKH before it enters famous Khunjerab Pass.
Effect of Chrysanthemum indicum Extract on NF-[kappa]B p65 Unit Protein, SOST, and DKK-1 Levels.
An electronic monitoring system will be built in Khunjerab and Sost dry port ensuring a real-time monitoring of the border crossing.
Welsh repre redu sost Ctw Anglesey Council's executive committee will vote on the suspension at a meeting at 10am on Monday.
The passenger lines run from Kashi and Taxkorgan, also in southern Xinjiang, to Pakistan's Northern Gilgit and Sost Pass respectively.
In the present study, we selected the following genes, sclerostin (Sost), low density lipoprotein receptor-related protein 6 (Lrp6), transcription factor 7-like 2 (Tcf7l2), alkaline phosphatase (Alpl), Mitogen-activated protein kinase kinase 6 (Map2k6) and nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4) involved in the significant signaling pathway "role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis" (Figure 4) for additional evaluation.
AMG 785 is thought to increase bone formation by inhibiting sclerostin, a protein encoded by the SOST gene in osteocytes that downregulates osteoblast-mediated bone formation.
AMG 785 is thought to increase bone formation on quiescent surfaces by inhibiting sclerostin, a protein encoded by the SOST gene in osteocytes that down-regulates osteoblast-mediated bone formation.