SOST


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SOST

A gene on chromosome17q11.2 that encodes sclerostin, a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

Molecular pathology
Loss-of-function mutations in SOST are linked to sclerosteosis; a deletion downstream of SOST causes reduced sclerostin expression, resulting in a milder sclerosteosis (van Buchem disease).
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On his way from Sost to Khunjerab Pass, the tourists do come across Pakistani soldiers from Frontier Works Organisation (FWO) who are found continuously on watch, well equipped and ready to open the road due to any landslide blockade.
SOST, osteoblastlardaki Wnt ligani ve LRP5/6 koreseptorleri arasindaki karsilikli etkilesimi antagonize etmesiyle ve boylece dogal Wnt sinyalini inhibe etmesiyle kemik formasyonunun bir negatif regulatorudur (17,48).
Sclerostin, a protein product of the SOST gene, inhibits osteoblast activity via antagonism of the wnt and BMP signaling pathways and plays a key role in the regulation of bone formation.
Since 1986, PTDC's subsidiary, Pakistan Tours Ltd, has been successfully running bus services between Pakistan and China from Sost to Taxkugan.
The Sost Dry Port which used to generate income from taxes, custom duties and other charges is now on the verge of obliteration.
Los resultados que se obtienen cuando se aplican las distintas expresiones matematicas a los valores de los indicadores en las diferentes ciudades se muestran en las siguientes tablas, donde se recogen el nombre de la ciudad, las iniciales de los diferentes indicadores, el valor que alcanza cada indicador en cada ciudad (fila I), los valores considerados optimo y maximo de cada indicador y en cada ciudad (filas Io e IM), y los valores de sostenibilidad sensu stricto y sensu lato para cada indicador (filas Sost ss y Sost sl) y el valor de sostenibilidad media (SM, cuadros amarillo o verde).
Afghanistan can now transit through Karachi, Qasem, Gwadar, Wagah and Sost ports.
Sklerostin Geni (SOST): SOST geni osteositler tarafindan uretilen ve kemik olusumunu inhibe eden sklerostin proteinini kodlamaktadir.
Sclerostin, a product of the SOST gene, is a glycoprotein produced mainly by osteocytes, the most abundant cell type of bone.
India has objections to various Chinese funded projects in PoK -- Neelum Jhelum project, Diamer Bhasha Dam, extension and upgradation of Karakoram Highway, Sost Dry Port and Bunji Dam.
Giving details, PHD Health Services Additional Director Dr Mubashir Malik and Holy Family Hospital (Rawalpindi) Director Emergency Dr Raja Shafiq Sarwar, who are supervising the medical teams, said that teams visited various camps of IDPs located in areas including Gulmit, Nagar, Sost, Minapin , Shasket, Aliabad, Altit and Baltit.
On July 1, 2010 he will take over from Jorg Sost, who will be retiring toward the middle of the year.