SOLVD


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SOLVD

Cardiology A series of clinical trials–Studies of Left Ventricular Dysfunction that evaluated the effect of antihypertensives–eg, with enalapril, an ACE inhibitor, on M&M in Pts with CHF. See ACE inhibitor, Congestive heart failure Consensus II, Enalapril.
References in periodicals archive ?
Among the 5,331 SOLVD patients with left ventricular dysfunction of ischemic etiology, the adjusted relative risk of all-cause mortality in patients who reported consuming one to two drinks daily was 0.
In the 3-year SOLVD (Studies of Left Ventricular Dysfunction) trial, more than 6,700 American, Canadian, and Belgian patients took enalapril or placebo; they were followed for an additional 9 years to assess life expectancy.
Philip Jong presented the results of the Extended Studies of Left Ventricular Dysfunction (XSOLVD), an unprecedented 12-year follow-up study of participants in the landmark SOLVD prevention and treatment trials.
The original SOLVD trials randomized nearly 7,000 Americans, Canadians, and Belgians with congestive heart failure (CHF) or asymptomatic left ventricular dysfunction to enalapril or placebo, then followed them for a mean of 3.
8% of the original SOLVD participants were tracked down 12 years after the studies had formally ended to learn how the patients had subsequently fared.
At the conclusion of the SOLVD prevention trial, patients with asymptomatic left ventricular dysfunction who received enalapril had significantly lower rates of MI and hospitalization than those who received placebo.
At the end of the SOLVD treatment trial, patients with CHE in the enalapril arm had a significant survival advantage: 64%, vs.
The ability of bypass surgery to blunt this risk was suggested by a retrospective analysis of the SOLVD results, which included 1,109 patients with diabetes.