SOD3

SOD3

A gene on chromosome 4p15.3-p15.1 that encodes an extracellular superoxide dismutase which binds superoxide byproducts of oxidative phosphorylation, converting them to hydrogen peroxide and diatomic oxygen. SOD3 is thought to protect the brain, lungs and other tissues from oxidative stress.
References in periodicals archive ?
By contrast, the expression levels of GPX3, SOD1, and SOD3 increased in embryos treated with H2O2, while those of GPX4 and SOD2 decreased compared with the respective controls (Fig.
The concentration of superoxide dismutase 2 (SOD2) and 3 (SOD3), the concentration of catalase (CAT) specific activity of glutathione peroxidase (GSH-Px), the concentration of glutathione (GSH) and total protein content (tP) were determined in the supernatant fluid.
The less common allele in SOD3 rs699473 was associated with an increased risk of high-grade disease (T > C: OR = 1.40, 95% CI: 1.04-1.89).
Potential markers that are functionally associated with extracellular matrix included Abi3bp, Mfap4, Rarres2, Dcn, Dpt, Cilp, and Sod3 as well as the well-known gene Itgbl1 (integrin, beta-like 1; with EGF-like repeat domains) (Figure 4(a)).
Folz, "Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression," Free Radical Biology & Medicine, vol.
Specific proteins, such as asporin and tenomodulin, were limited to tendons, while versican, proteoglycan 4, and SOD3 were ligament-specific (Figure 1).
For example, radicals generated by hyperactivated neutrophils are cleared via superoxide dismutase 3 (SOD3) from mesenchymal stem cells (MSCs) [83].
cardiomyopathy In T2DM: In vivo [up arrow] Sirt1 and Sirt2 [down arrow] Sirt3, which was initially elevated [up arrow] [down arrow] [H.sub.2][O.sub.2]- Sirt1, caspase 3 induced apoptosis Sirt3, In vitro Sirt4, and Sirt7 Most effects [up arrow] SOD1, In vivo abolished SOD3, GPx1, Apo-lipoprotein when using catalase.
Findings revealed that SNPs in inflammatory gene markers for IL1[beta], TNF[alpha], and CD40 were determinants for individuals in the vata subgroup, whereas those for oxidative stress gene markers for SOD3 and PON1 were stronger determinants for individuals in the pitta subgroup, and only negligible associations of SNPs for SOD3 and PTPN22 gene markers were correlated with individuals in the kapha subgroup [133].
Our most recent study (collaborating with Martine Culty's group) examined testicular effects after gestational exposure to DEHP at relatively low dose and revealed that the redox markers (Nqo1, Sod2, Sod3, Trx, Gst, and Cat) were significantly altered at PND3, while being attenuated when combined with GEN, suggesting the involvement of cellular stress in short-term DEHP effects and a protective effect of GEN [13].
Many genes have multiple miRNAs target sites such as helicase with zinc finger (HELZ), espin (ESPN), cytochrome P450 family 2 subfamily C member 18 (CYP2C18), snail family transcriptional repressor 2 (SNAI2), and superoxide dismutase 3 (SOD3).
Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ- coupled two-dimensional LC-MS/MS.