SOD2

SOD2

A gene on chromosome 6q25.3 that encodes a mitochondrial  superoxide dismutase which binds superoxide byproducts of oxidative phosphorylation, converting them to hydrogen peroxide and diatomic oxygen.

Molecular pathology
SOD2 mutations are associated with idiopathic cardiomyopathy, premature ageing, sporadic motor neurone disease, and cancer.
References in periodicals archive ?
This inhibition is associated with increased expression of forkhead box O (FOXO) 3a and metallothionein II and increased protein content of FOXO3a, SOD2, and catalase [103].
Superoxide dismutase (SOD2) gene is an important gene responsible for the protection against oxidative stress [39].
Mitochondrial SOD2 was repressed in ischemic rat models and was upregulated by DQP, suggesting that DQP has a protective antioxidative effect on the heart.
Many other SNPs of different genes involved in lipid metabolism, such as lipin 1 (LPIN1), oxidative stress, such as superoxide dismutase 2 (SOD2), and fibrogenesis, such as Kruppel-like factor 6 (KLF6), have been associated with the severity of liver damage in different studies on NAFLD patients [8-12].
Meanwhile, upregulation of NOX4 and downregulation of SOD2 after radiation also proved this ROS change (Figures 1(e) and 1(f))).
Primary antibodies against GAPDH (FL-335), p-CaMKII [alpha] (22B1), CaMKII (M-176), AMPK [alpha]1/2 (H-300), SOD2 (FL-222), p21 (C-19), peroxidase-conjugated secondary antibodies for Western blot analysis, and FITC-conjugated antibodies for immunofluorescence study were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
Park et al., "The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms," Cancer, vol.
Comparative proteomics of monocytes in relation to BMD was first reported in 2008 from premenopausal Chinese women with low versus high BMD condition, wherein two-dimensional electrophoresis was employed and 5 proteins were differentially abundant including Ras suppressor protein 1 (RSU1), gelsolin (GSN), and manganese containing superoxide dismutase (SOD2) which were upregulated, while glutathione peroxidase 1 (GPX1) and prolyl 4-hydroxylase b subunit (P4HB) were downregulated in low BMD condition [36].
Specifically, lethe binds to the active NF-[kappa]B subunit p65 (RelA) and prevents it from binding to the promoters of target genes, thus reducing the production of a number of inflammatory proteins, such as IL-6, IL-8, and superoxide dismutase 2 (SOD2).
Real-time PCR amplification was performed using Power SYBR qRT-PCR kits (Applied Biosystems, Foster City, CA) on a QuantStudio 5 analyzer (Applied Biosystems) for the following primers: heme oxygenase 1 (HO-1), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX1), superoxide dismutase 2 (SOD2), thioredoxin 1 (TRX1), platelet-derived growth factor subunit b (PDGFb), transforming growth factor beta 1 (TGF[beta]1), matrix metallopeptidase 9 (MMP9), arginase 1 (ARG1), lymphocyte antigen 6 complex (Ly6c), CD68, neutrophil elastase (ELANE), and inducible nitric oxide synthase (iNOS).
The levels of superoxide dismutase (Sod2) and Sirtuin 1 (Sirt1), a deacetylation enzyme, were detected by Western blotting.
By contrast, we observed increases in isoaspartyl peptidase/L-asparaginase (ASRGL1) and mitochondrial superoxide dismutase [Mn] (SOD2).