SOD1


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Related to SOD1: SOD2, SOD3, G93A

SOD1

A gene on chromosome 21q22.11 that encodes a soluble, copper- and zinc-binding cytoplasmic protein, which is responsible for destroying free superoxide radicals in the body, converting natural—but harmful—superoxide radicals to molecular oxygen and hydrogen peroxide.

Molecular pathology
SOD1 mutations have been linked to familial amyotrophic lateral sclerosis.
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References in periodicals archive ?
Lennon et al., "Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria," Neuron, vol.
ARE is a cis-regulatory element with specific DNA sequences that are present in the upstream regulatory regions of genes encoding a series of detoxifying enzymes such as HO-1 and SOD1 [4].
Adult B6.Cg-Tg(SOD1-G93A)1Gur/J mice expressing high copy number of mutant human SOD1 with a Gly93Ala substitution ([SOD1.sup.G93A]) and adult B6SJLTgN(SOD1)2Gur mice expressing wild-type human SOD1 were originally obtained from Jackson Laboratories (Bar Harbor, ME, USA).
SOD1 und amyotrophic lateral sclerosis: mutation and oligomerization.
Gene expression patterns related to the apoptosis pathway (pro-apoptotic p53, and Bax), apoptosis protease-activating factor (caspase-9 and caspase-3), anti-apoptotic (Bcl-2) and oxidative stress (Cat, Gpxla and Sod1) were also examined to elucidate the potential molecular mechanism underlying the induction of oxidative stress and apoptosis by the PFOS and ZnO-NPs.
The yeast strains used in this study were the wild-type strain YPH250 (MATa trp1-[DELTA]1 his3-[DELTA]200 lys2-801 leu2-[DELTA]1 ade2-101 ura3-52) and its isogenic mutants [DELTA]sod1 (as YPH250 but sod1::URA3), [DELTA]sod1[DELTA]sod2 (as YPH250 but sod1::kanMX2 sod2[DELTA]::TRP1), [DELTAc]ta1[DELTAc]tt1 (as YPH250 but cta1::TRP1 ctt1::URA3), [DELTA]yap1 (as YPH250 but yap1-[DELTA]1::HIS3), and [DELTA]gsh1 (as YPH250 but gsh1::LEU2).
VEGF-B was not detectable in quiescent astroglia in SOD1 mice, but its expression became prominent in activated astrocytes thought to maintain survival of motor neurons after injury [31].
The molecules that catalyze phase II reactions can be further classified as "direct" or "indirect." "Direct" antioxidants include SOD1 and GSH, which directly quench ROS.
DJ-1, GCLc, SOD1, and SOD2 antibodies were obtained from Cell Signaling Technology (CST, USA).
There are three main endogenous antioxidant systems: superoxide dismutase 1 (SOD1), superoxide dismutase 2 (SOD2), and catalase (CAT).