mediated pathogenesis of Amyotrophic Lateral Sclerosis.
Lennon et al., "Amyotrophic lateral sclerosis-associated SOD1
mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria," Neuron, vol.
EZH2 Suppresses SOD1
Transexpression in Lung in TAC-Induced PAH Mice.
ARE is a cis-regulatory element with specific DNA sequences that are present in the upstream regulatory regions of genes encoding a series of detoxifying enzymes such as HO-1 and SOD1
Adult B6.Cg-Tg(SOD1-G93A)1Gur/J mice expressing high copy number of mutant human SOD1
with a Gly93Ala substitution ([SOD1.sup.G93A]) and adult B6SJLTgN(SOD1
)2Gur mice expressing wild-type human SOD1
were originally obtained from Jackson Laboratories (Bar Harbor, ME, USA).
und amyotrophic lateral sclerosis: mutation and oligomerization.
Gene expression patterns related to the apoptosis pathway (pro-apoptotic p53, and Bax), apoptosis protease-activating factor (caspase-9 and caspase-3), anti-apoptotic (Bcl-2) and oxidative stress (Cat, Gpxla and Sod1
) were also examined to elucidate the potential molecular mechanism underlying the induction of oxidative stress and apoptosis by the PFOS and ZnO-NPs.
The yeast strains used in this study were the wild-type strain YPH250 (MATa trp1-[DELTA]1 his3-[DELTA]200 lys2-801 leu2-[DELTA]1 ade2-101 ura3-52) and its isogenic mutants [DELTA]sod1 (as YPH250 but sod1
::URA3), [DELTA]sod1[DELTA]sod2 (as YPH250 but sod1
::kanMX2 sod2[DELTA]::TRP1), [DELTAc]ta1[DELTAc]tt1 (as YPH250 but cta1::TRP1 ctt1::URA3), [DELTA]yap1 (as YPH250 but yap1-[DELTA]1::HIS3), and [DELTA]gsh1 (as YPH250 but gsh1::LEU2).
VEGF-B was not detectable in quiescent astroglia in SOD1
mice, but its expression became prominent in activated astrocytes thought to maintain survival of motor neurons after injury .
The molecules that catalyze phase II reactions can be further classified as "direct" or "indirect." "Direct" antioxidants include SOD1
and GSH, which directly quench ROS.
DJ-1, GCLc, SOD1
, and SOD2 antibodies were obtained from Cell Signaling Technology (CST, USA).
There are three main endogenous antioxidant systems: superoxide dismutase 1 (SOD1
), superoxide dismutase 2 (SOD2), and catalase (CAT).