Daryl Bosco, assistant professor of neurology and lead author of the study, said in the release: "This common ALS pathology between sporadic and familial ALS means that current gene silencing and immunotherapeutic treatments being developed in academic and commercial labs that target the mutant SOD1
gene may be extended to target non-mutant SOD1
protein found in sporadic ALS cases.
Amazona farinosa: The following loci were fixed for the same allele in all taxa: ACP, ADA, AK, EAP, ES-MA, ES-NP1, ES-NP2, ES-NP3, FUM, GDA, GLUD, GOT1, GOT2, [Alpha]GPD, GPI, GSR, MDH1, MDH2, ME1, ME2, MPI, NADPH, PEP-LA, PEP-LGG, PGD, PGM1, PGM2, SOD1
, SOD2, SORDH.
These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1
, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).