SOCS6

(redirected from SOCS4)

SOCS6

A gene on chromosome 18q21.2 that encodes a protein belonging to the cytokine-induced STAT inhibitor (CIS)—i.e., suppressor of cytokine signalling (SOCS); STAT-induced STAT inhibitor (SSI)—protein family, which are cytokine-inducible (e.g., by CSF2/GM-CSF, erythropoeitin) negative regulators of cytokine signalling.

Molecular pathology
SOCS6 is highly expressed in chronic myeloid leukaemia (CML) and erythroleukaemia.
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References in periodicals archive ?
However, there are closer structures in pairs among the SOCS proteins family: SOCS1 and SOCS3, SOCS4 and SOCS5, SOCS6 and SOCS7, and SOCS2 and CIS.
Weathering the (cytokine) storm: a protein's key role A protein called SOCS4 has been shown to act as a brake on the immune system's runaway reaction to flu infection, providing a possible means of minimizing the impact of flu pandemics.
Scientists from Melbourne's Walter and Eliza Hall Institute have found that without SOCS4 the immune response to influenza infection is slowed and there is a vast increase in the number of damaging inflammatory molecules in the lungs.
According to Kedzierski, removing SOCS4 upset the normal immune response to influenza infection.
"Our research suggests that SOCS4 keeps this response under control, preventing a cytokine storm in the lungs that can lead to a buildup of fluid that restricts breathing and can ultimately result in death."
Washington, May 9 ( ANI ): Researchers have shown that a protein called SOCS4 can act as a handbrake on the immune system's runaway reaction to flu infection, providing a possible means of minimising the impact of flu pandemics.
Dr Kedzierski said removing SOCS4 upset the normal immune response to influenza infection.
Our research suggests that SOCS4 keeps this response under control, preventing a cytokine storm in the lungs that can lead to a build up of fluid that restricts breathing and can ultimately result in death."
Dr Nicholson said drugs that enhanced or mimicked SOCS4 action could be a useful way of treating pandemic or more aggressive flu strains, as well as other infections.
Indeed, CIS and SOCS2, SOCS1 and SOCS3, SOCS4 and SOCS5, and SOCS6 and SOCS7 all form related pairs [22].
For example, CIS, SOCS1, SOCS2, and SOCS3 have relatively short (50-80 residues) N-terminal regions, whereas SOCS4, SOCS5, SOCS6 and SOCS7 have longer N-terminal regions of up to 380 residues [22, 25, 26].
Considerably less work has been done on the remaining two pairs of SOCS proteins, SOCS4 and 5 and SOCS6 and 7.