SOCS3


Also found in: Acronyms.

SOCS3

A gene on chromosome 17q25.3 that encodes a protein which interacts with multiple activated proteins of the tyrosine kinase signalling pathway, including IGF1 receptor, insulin receptor and JAK2.

Molecular pathology
SOCS3 is thought to be a susceptibility gene for atopic dermatitis.
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To further explore the role of the IL-6/STAT3/SOCS3 signaling pathway in cardiomyocytes and cardiac fibroblasts stimulated by HG, we firstly detected the mRNA expression of SOCS3 in cardiomyocytes and cardiac fibroblasts.
RNA-Seq data also revealed that the expression of SOCS3 was significantly elevated to 4.11-fold by E2 (log2 fold change = 2.04; [P.sub.adj] = 1.76E - 08) and to 5.00-fold by DPN (log2 fold change = 2.32; [P.sub.adj] = 4.84E - 13), but was not changed by PPT, compared with the control group.
The antibodies against IL10 (sc1783), I[kappa]B[alpha] (sc1643), pIkK (sc7977), pSTAT1 (sc7988), TNF[alpha] (sc8301), and SOCS3 (sc7009) were from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
We further observed the SOCS3 transcription increased obviously after treatment with 10% Kidney-replenishing herb (Figure 10(b)).
What is more, the codeletion of PTEN and suppressor of cytokine signaling 3 (SOCS3) could lead to the change of uninjured CST axons to denervation of the spinal cord [27].
The human SOCS3 maps to chromosome 17q25.3 and consists of two exons spanning 2.729 nucleotides.
Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity.
SOCS3 deficiency promotes Ml macrophage polarization and inflammation.
A new polycythaemia veraassociated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses.