SOCS2


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SOCS2

A gene on chromosome 12q that encodes a member of the suppressor of cytokine-signalling—i.e., STAT-induced STAT inhibitor—family, which are cytokine-inducible negative regulators of cytokine signalling. SOCS2 expression is induced by cytokines (e.g., erythropoietin, CSF2/GM-CSF, IL10 and interferon-gamma), and it provides a negative feedback loop to attenuate cytokine signalling. SOCS2 interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in regulating IGF1R-mediated cell signalling.
References in periodicals archive ?
2 No definido aun SOCS2 605117 No definido aun No definido aun SOCS3 604176 No definido aun No definido aun *Tipos especiales de Sindrome Dismorfogenico con importantes rasgos de polidistrofia osea, los cuales son homoalelicos al mismo gen afectado, pero con varianza fenotipica.
SOCS2 and SOCS3 contribute to GH resistance in malnourished liver IGF-I deficient mice.
Mapping, tissue distribution and polymorphism study of the porcine SOCS2 and SOCS3 genes.