SOCS2


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SOCS2

A gene on chromosome 12q that encodes a member of the suppressor of cytokine-signalling—i.e., STAT-induced STAT inhibitor—family, which are cytokine-inducible negative regulators of cytokine signalling. SOCS2 expression is induced by cytokines (e.g., erythropoietin, CSF2/GM-CSF, IL10 and interferon-gamma), and it provides a negative feedback loop to attenuate cytokine signalling. SOCS2 interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in regulating IGF1R-mediated cell signalling.
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References in periodicals archive ?
and degradation of target proteins [129], using specific interaction with an alternate E3 ligase component named heme-oxidised IRP2 ubiquitin ligase-1 (HOIL-1) [126], and as SOCS2, SOCS6 also has the ability to degrade other SOCS proteins, including SOCS7 [163].
Like CIS, SOCS2 is induced and regulated signalling by cytokines that activate STAT5, including IL-2 [78, 79] and shown to exert an antagonistic role in the SOCS1- and SOCS3mediated negative regulation of IL-2 and IL-3 signalling, respectively [79].
Increased expression of SOCS2 in malignancies like chronic myeloid leukemia (CML) [219,220] could contribute to transformation by negative interference with other SOCS molecules that normally would suppress tumor development.
example exists in solid tumours, as patients with active acromegaly and colonic polyps have shown a significantly increased SOCS2 expression, which mediated a reduction in SOCS1 expression, leading to elevated STAT5b levels, and likely leading to exaggerated GH-mediated proliferation of colonic epithelial cells [252].
More recent data suggest that administering probiotics can reduce H pylori induced gastritis and therefore the risk of associated gastric cancer by the increased cellular expression of SOCS2 and SOCS3 [274].
Shuai, "The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities," The Journal of Biological Chemistry, vol.
Johnston, "SOCS2 can enhance interleukin2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation," Molecular and Cellular Biology, vol.
Zhanget al., "Erythropoietin up-regulates SOCS2 in neuronal progenitor cells derived from SVZ of adult rat," NeuroReport, vol.
Turnley, "SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation," The Journal of Biological Chemistry, vol.
Sutherland et al., "Socs2 and Elf5 mediate prolactin-induced mammary gland development," Molecular Endocrinology, vol.
Persson et al., "The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels," PLoS ONE, vol.
Lorentzon et al., "SOCS2 negatively regulates growth hormone action in vitro and in vivo," The Journal of Clinical Investigation, vol.