SOCS1


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SOCS1

A gene on chromosome 16p13.13 that encodes a member of the suppressor of cytokine-signalling—i.e., STAT-induced STAT inhibitor—family, which are cytokine-inducible negative regulators of cytokine signalling. SOCS1 expression is induced by cytokines (e.g., IL2, IL3, erythropoietin, CSF2/GM-CSF and interferon-gamma), and it provides a negative feedback loop to attenuate cytokine signalling.
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Gerec ve Yontemler: SOCS1, SOCS3 genlerinin promotor metilasyonu, metilasyon spesififk PCR ile incelendi.
Bulgular: SOCS1 geninde CpG adaciklarinda hastalikla i1iski1i metilasyon bulunamadi.
The researchers also showed that the reintroduction of SOCS1 into tumour cells locked them into a permanent dormant state known as cell senescence preventing them from multiplying wildly as is typical of cancer cells.