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Gerec ve Yontemler: SOCS1, SOCS3 genlerinin promotor metilasyonu, metilasyon spesififk PCR ile incelendi.
Bulgular: SOCS1 geninde CpG adaciklarinda hastalikla i1iski1i metilasyon bulunamadi.
Expression of SOCS1 and SOCS3 genes leads to reduced JAK and STAT phosphorylation via binding of the JH 1 domain and cytokine receptor of JAK, respectively (6), (7), (8).
The researchers also showed that the reintroduction of SOCS1 into tumour cells locked them into a permanent dormant state known as cell senescence preventing them from multiplying wildly as is typical of cancer cells.