SOCS7

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SOCS7

A gene on chromosome 17q12 that encodes a protein that regulates signalling cascades protein ubiquitination and/or sequestration. SOCS7 is involved in insulin signalling and glucose homeostasis through insulin receptor substrate 1 (IRS1) ubiquitination, followed by proteasomal degradation. It also inhibits prolactin, growth hormone and leptin signalling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their DNA binding.
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References in periodicals archive ?
There are seven SOCS family proteins: SOCS-1, SOCS-2, SOCS-3, SOCS-4, SOCS-5, SOCS-6, and SOCS-7, each of which has a central SH2 domain, an amino-terminal domain of variable length and sequence, and a carboxy-terminal 40-amino-acid module known as the SOCS box (Tamiya et al.
Mangia, "Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-y in Huh-7 cells," Journal of General Virology, vol.
Yuan et al., "Defective interleukin-4/Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3, SOCS-7, and CISH in colon cancer cells," Journal of Interferon and Cytokine Research, vol.