SOCS2

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SOCS2

A gene on chromosome 12q that encodes a member of the suppressor of cytokine-signalling—i.e., STAT-induced STAT inhibitor—family, which are cytokine-inducible negative regulators of cytokine signalling. SOCS2 expression is induced by cytokines (e.g., erythropoietin, CSF2/GM-CSF, IL10 and interferon-gamma), and it provides a negative feedback loop to attenuate cytokine signalling. SOCS2 interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in regulating IGF1R-mediated cell signalling.
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References in periodicals archive ?
There are seven SOCS family proteins: SOCS-1, SOCS-2, SOCS-3, SOCS-4, SOCS-5, SOCS-6, and SOCS-7, each of which has a central SH2 domain, an amino-terminal domain of variable length and sequence, and a carboxy-terminal 40-amino-acid module known as the SOCS box (Tamiya et al.
Sadowski, "Insulin induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 skeletal muscle cells is mediated by Stat5*," The Journal of Biological Chemistry, vol.
Edery, "Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction," FEBS Letters, vol.