FRS2

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FRS2

A gene on chromosome 12q15 that encodes an adapter protein which links activated FGR and NGF receptors to downstream signalling pathways. FRS2 plays a key role in activating MAP kinases and in phosphorylating  PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. FRS2 modulates signalling via SHC1 by competing with it for a common binding site on NTRK1. It is usually part of heteromultimeric protein complexes, and it is highly expressed in the heart, brain, spleen, lungs, liver, skeletal muscle, kidneys and testes.
References in periodicals archive ?
[121] showed that P aeruginosa SNT1 biosynthesized nanostructured selenium by biotransforming selenium oxyanions to spherical amorphous allotropic elemental red selenium both intracellularly and extracellularly.
Com2: "cph1" [right arrow] "snt1", "sif2", "hst1", "hos2", "hos4" [right arrow] "set3", "zds1".
Social Network Ties SNT1 I maintain close social relationships with some members in the virtual learning community.