FRS2

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FRS2

A gene on chromosome 12q15 that encodes an adapter protein which links activated FGR and NGF receptors to downstream signalling pathways. FRS2 plays a key role in activating MAP kinases and in phosphorylating  PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. FRS2 modulates signalling via SHC1 by competing with it for a common binding site on NTRK1. It is usually part of heteromultimeric protein complexes, and it is highly expressed in the heart, brain, spleen, lungs, liver, skeletal muscle, kidneys and testes.
References in periodicals archive ?
SNT has announced a 40-day mourning over his death.
SnT explained that a web platform is used to bring all this information together to provide airport monitoring and scenario simulation, while mobile apps provide security staff with on-the-ground operational information and incident support.
Murad Halabi, SNT spokesperson said: "They were amazed at how light the machine was, and had never worked with a compressor that can be towed behind a small van or passenger car yet is still powerful enough to support two breakers."
"They were amazed at how light the machine was, and had never worked with a compressor that can be towed behind a small van or passenger car; yet is still powerful enough to support two breakers," observed Murad Halabi, a spokesperson at SNT.
SNT is growing, there would be taxes on the gains), possible accounting fees (a funded trust must file a tax return each year just like people do), and attorney fees (whether they are serving as trustee/co-trustee, or providing periodic consultation to ensure that the SNT is in compliance with evolving rules and regulations).
(3,5) With the advent of percutaneous renal procedures, it became possible to convert a standard nephrostomy tube (SNT) to CNT using percutaneous techniques under local anesthesia for patients who were poor operative risk.
Polyorchidism, alternatively supernumerary testes (SNT), is a condition where an individual is born with more than two testicles [1].
Additionally, who the individual is and what assets they have will be a pivotal component in determining which type of special needs trust (SNT) might be needed.
"Consequently, even if the Applicant's mark was referred to as 'sain ella,' the word 'saint' could easily be slurrd to 'snt' and 'snt ella,' with the emphasis being on the word 'ella' and the name being misheard as the more recognised word 'stella.'"
A subset of samples were also subjected to a seroneutralization test (SNT) as described (7).
We used a popular traditional Chinese herbal formula, "Sini Tang" (SNT), first described by Zhang (150-219 A.D.) in his book "Treatise on cold-induced diseases," a medical collection from ancient China for this study [12].